POU5F1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of POU5F1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POU5F1 at tissue level.

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0009786Biological processregulation of asymmetric cell division
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006355Biological processregulation of DNA-templated transcription
GO_0009653Biological processanatomical structure morphogenesis
GO_0001824Biological processblastocyst development
GO_0009611Biological processresponse to wounding
GO_0001714Biological processendodermal cell fate specification
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0003723Molecular functionRNA binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOU5F1
Protein namePOU domain transcription factor Oct4 isoform 3
POU domain protein
POU class 5 homeobox 1
POU class 5 homeobox 1 transcript variant OCT4B4
POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)
POU class 5 homeobox 1 transcript variant OCT4B5
POU domain class 5 transcription factor 1
POU domain, class 5, transcription factor 1
POU class 5 homeobox 1 (POU class 5 homeobox 1 transcript variant OCT4B1) (POU class 5 homeobox 1 transcript variant OCT4B2) (POU class 5 homeobox 1 transcript variant OCT4B3)
Putative truncated POU domain class 5 transcription factor 1
POU domain transcription factor OCT4
POU class 5 homeobox 1 transcript variant OCT4B6
SynonymsOCT4
OCT3
OTF3
DescriptionFUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. .

AccessionsA7WPM2
A7WPM5
ENST00000259915.13 [Q01860-1]
A7WPM6
ENST00000376243.8 [Q01860-2]
B5B8N7
B5B8N9
A7WPL9
ENST00000454714.6 [Q01860-1]
B5B8P7
A7WPN0
D5K9S1
D5K9R5
A7WPM8
A0A0K0KMS3
ENST00000429603.2 [Q01860-1]
ENST00000441888.7
B5B8Q2
M1S623
ENST00000433063.6 [Q01860-1]
C3RUE0
D5K9R1
B5B8P1
ENST00000433348.2 [Q01860-2]
E9LR75
A7WPM9
A0A0K0KMI2
B5B8P8
ENST00000512818.5
D5K9R4
D5K9R7
D2IYK3
A0A1W2PP83
E9LR79
B5B8Q3
ENST00000429314.2 [Q01860-2]
ENST00000471529.6
B5B8P9
ENST00000412166.6 [Q01860-2]
D5K9R2
ENST00000383524.4 [Q01860-1]
E9LR73
B5B8P2
B5B8Q4
F2Z381
ENST00000434616.2 [Q01860-1]
ENST00000437747.6 [Q01860-1]
D5K9Q9
B5B8P5
B5B8P6
D5K9R8
B5B8Q1
D5K9Q6
ENST00000640651.1
B5B8P0
D5K9R3
ENST00000513407.1
D5K9Q7
E9LR77
A7WPM3
A7WPM1
B5B8N8
Q01860
A0A0K0KMW9
ENST00000639883.1
A7WPM0
D5K9R9
ENST00000606567.6
ENST00000419095.2 [Q01860-2]
A7WPM7
B5B8P3
B5B8Q0
B5B8P4
D5K9Q3
ENST00000451077.6 [Q01860-2]
A7WPM4