LARP7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_1904871Biological processpositive regulation of protein localization to Cajal body
GO_0006397Biological processmRNA processing
GO_1905382Biological processpositive regulation of snRNA transcription by RNA polymerase II
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1990438Biological processU6 2'-O-snRNA methylation
GO_0008380Biological processRNA splicing
GO_0048024Biological processregulation of mRNA splicing, via spliceosome
GO_0030154Biological processcell differentiation
GO_0000494Biological processbox C/D sno(s)RNA 3'-end processing
GO_0032897Biological processnegative regulation of viral transcription
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0120259Cellular component7SK snRNP
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_0017070Molecular functionU6 snRNA binding
GO_0097322Molecular function7SK snRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLARP7
Protein nameLa ribonucleoprotein 7, transcriptional regulator
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
LARP7 protein
La-related protein 7 (La ribonucleoprotein domain family member 7)
SynonymsHDCMA18P
DescriptionFUNCTION: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function . Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II . The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation . The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) . LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex . LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing . Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif . U6 snRNA processing is required for spermatogenesis (By similarity). .

AccessionsENST00000694901.1
ENST00000694896.1
D6R9Z6
ENST00000694899.1
D6RBH8
ENST00000651579.1 [Q4G0J3-1]
ENST00000693375.1
H0YA82
ENST00000509061.5 [Q4G0J3-1]
A0A8I5KQG7
A0A8Q3SHL6
ENST00000694897.1
A0A8Q3SHN7
ENST00000694898.1
ENST00000694894.1 [Q4G0J3-1]
ENST00000344442.10 [Q4G0J3-1]
ENST00000505034.5
ENST00000694891.1
ENST00000512589.6
ENST00000513553.5
ENST00000511529.2
D6RF49
Q4G0J3
ENST00000505034.6 [Q4G0J3-1]
ENST00000693442.1
A0A8Q3SHH4
ENST00000505216.2
ENST00000509622.5
ENST00000690008.1
A0A8Q3SHF1
ENST00000689844.1
ENST00000694900.1
A0A8I5KYN2
A0A8Q3WK75
A0A8I5KUI4
D6RF22
D6RFF0
A0A8Q3SHG9
Q96IZ8
A0A8I5KSZ3
ENST00000508577.5
ENST00000692416.1
ENST00000694895.1
ENST00000684864.1