CDK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDK2 at tissue level.

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0010468Biological processregulation of gene expression
GO_0006813Biological processpotassium ion transport
GO_0007265Biological processRas protein signal transduction
GO_1905784Biological processregulation of anaphase-promoting complex-dependent catabolic process
GO_0006281Biological processDNA repair
GO_0051298Biological processcentrosome duplication
GO_0031453Biological processpositive regulation of heterochromatin formation
GO_0007165Biological processsignal transduction
GO_0051301Biological processcell division
GO_0010389Biological processregulation of G2/M transition of mitotic cell cycle
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006260Biological processDNA replication
GO_0043687Biological processpost-translational protein modification
GO_0006338Biological processchromatin remodeling
GO_0071732Biological processcellular response to nitric oxide
GO_0006351Biological processDNA-templated transcription
GO_0051321Biological processmeiotic cell cycle
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045740Biological processpositive regulation of DNA replication
GO_0007346Biological processregulation of mitotic cell cycle
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0090398Biological processcellular senescence
GO_0031571Biological processmitotic G1 DNA damage checkpoint signaling
GO_0006468Biological processprotein phosphorylation
GO_0007099Biological processcentriole replication
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0032298Biological processpositive regulation of DNA-templated DNA replication initiation
GO_0097124Cellular componentcyclin A2-CDK2 complex
GO_0000805Cellular componentX chromosome
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0097135Cellular componentcyclin E2-CDK2 complex
GO_0097134Cellular componentcyclin E1-CDK2 complex
GO_0000806Cellular componentY chromosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0000781Cellular componentchromosome, telomeric region
GO_0000793Cellular componentcondensed chromosome
GO_0001673Cellular componentmale germ cell nucleus
GO_0005768Cellular componentendosome
GO_0097123Cellular componentcyclin A1-CDK2 complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0019904Molecular functionprotein domain specific binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0097472Molecular functioncyclin-dependent protein kinase activity
GO_0005524Molecular functionATP binding
GO_0030332Molecular functioncyclin binding
GO_0035173Molecular functionhistone kinase activity
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameCDK2
Protein nameCyclin dependent kinase 2
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
SynonymsCDKN2
hCG_24992
DescriptionFUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 . Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks . .

AccessionsENST00000354056.4 [P24941-2]
ENST00000553376.5
G3V5T9
ENST00000555408.5
E7ESI2
ENST00000440311.6
G3V317
ENST00000555357.1
P24941
ENST00000266970.9 [P24941-1]