KLF12 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	21 studies	38% ± 18%	Explore
astrocyte	17 studies	46% ± 20%	Explore
oligodendrocyte precursor cell	16 studies	58% ± 21%	Explore
glutamatergic neuron	12 studies	45% ± 26%	Explore
GABAergic neuron	11 studies	53% ± 21%	Explore
fibroblast	11 studies	36% ± 13%	Explore
smooth muscle cell	11 studies	38% ± 15%	Explore
pericyte	10 studies	40% ± 16%	Explore
microglial cell	9 studies	35% ± 15%	Explore
T cell	9 studies	37% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	24% ± 12%	Explore
CD8-positive, alpha-beta T cell	8 studies	26% ± 13%	Explore
macrophage	7 studies	25% ± 17%	Explore
B cell	7 studies	33% ± 9%	Explore
natural killer cell	7 studies	39% ± 15%	Explore
CD4-positive, alpha-beta T cell	6 studies	30% ± 11%	Explore
neuron	6 studies	50% ± 24%	Explore
interneuron	6 studies	65% ± 14%	Explore
endothelial cell of lymphatic vessel	6 studies	33% ± 6%	Explore
mucosal invariant T cell	5 studies	28% ± 12%	Explore
cardiac muscle cell	5 studies	42% ± 12%	Explore
type I pneumocyte	5 studies	30% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	23% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	30% ± 12%	Explore
epithelial cell	4 studies	29% ± 11%	Explore
granule cell	4 studies	43% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	25% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	34% ± 14%	Explore
lymphocyte	4 studies	50% ± 23%	Explore
Mueller cell	4 studies	33% ± 16%	Explore
retinal cone cell	4 studies	37% ± 12%	Explore
retinal ganglion cell	4 studies	47% ± 24%	Explore
retinal rod cell	4 studies	24% ± 4%	Explore
ciliated cell	4 studies	35% ± 12%	Explore
gamma-delta T cell	4 studies	23% ± 5%	Explore
mesothelial cell	4 studies	35% ± 15%	Explore
regulatory T cell	4 studies	31% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	43% ± 6%	Explore
GABAergic interneuron	3 studies	48% ± 2%	Explore
progenitor cell	3 studies	51% ± 12%	Explore
GABAergic amacrine cell	3 studies	55% ± 14%	Explore
amacrine cell	3 studies	66% ± 11%	Explore
glycinergic amacrine cell	3 studies	71% ± 13%	Explore
hepatocyte	3 studies	58% ± 24%	Explore
retinal pigment epithelial cell	3 studies	52% ± 14%	Explore
neural progenitor cell	3 studies	43% ± 18%	Explore
connective tissue cell	3 studies	36% ± 10%	Explore
ependymal cell	3 studies	47% ± 25%	Explore
mast cell	3 studies	28% ± 6%	Explore
leukocyte	3 studies	50% ± 19%	Explore
oligodendrocyte	3 studies	29% ± 17%	Explore
mural cell	3 studies	50% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	38% ± 19%	Explore
eye	5 studies	36% ± 14%	Explore
heart	4 studies	38% ± 7%	Explore
lung	3 studies	23% ± 3%	Explore
adipose	3 studies	22% ± 1%	Explore
kidney	3 studies	30% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	1358.93	2636 / 2642	100%	18.66	704 / 705
kidney	100%	1389.47	89 / 89	94%	9.48	845 / 901
breast	99%	1144.40	454 / 459	93%	7.62	1039 / 1118
ovary	100%	1554.24	180 / 180	87%	5.13	372 / 430
liver	97%	1456.26	220 / 226	87%	5.86	353 / 406
thymus	98%	967.40	643 / 653	85%	5.09	515 / 605
skin	97%	1315.81	1748 / 1809	83%	7.86	392 / 472
lung	99%	1328.43	575 / 578	75%	4.30	867 / 1155
uterus	100%	1367.45	170 / 170	73%	5.34	336 / 459
esophagus	90%	1415.39	1307 / 1445	74%	5.28	136 / 183
stomach	100%	1044.27	359 / 359	64%	4.00	182 / 286
prostate	99%	1076.32	243 / 245	64%	2.57	322 / 502
adrenal gland	88%	535.14	228 / 258	69%	3.49	158 / 230
intestine	100%	1770.40	964 / 966	55%	2.93	288 / 527
bladder	100%	1352.05	21 / 21	50%	2.93	253 / 504
pancreas	40%	168.38	131 / 328	88%	5.21	156 / 178
blood vessel	100%	2864.61	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	8.85	29 / 29
spleen	100%	2037.17	241 / 241	0%	0	0 / 0
heart	100%	1393.92	857 / 861	0%	0	0 / 0
adipose	99%	1260.41	1197 / 1204	0%	0	0 / 0
muscle	99%	1039.43	794 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	78%	4.14	35 / 45
peripheral blood	64%	852.47	597 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	57%	2.62	46 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0003677	Molecular function	DNA binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	KLF12
Protein name	Krueppel-like factor 12 (Transcriptional repressor AP-2rep)
Synonyms	HSPC122 AP2REP
Description	FUNCTION: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
Accessions	ENST00000703967.1 [Q9Y4X4-1] ENST00000377669.7 [Q9Y4X4-1] Q9Y4X4

KLF12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review