Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 15 studies | 77% ± 14% | |
| GABAergic neuron | 10 studies | 64% ± 24% | |
| oligodendrocyte precursor cell | 7 studies | 29% ± 12% | |
| astrocyte | 6 studies | 37% ± 22% | |
| interneuron | 6 studies | 75% ± 15% | |
| neuron | 6 studies | 40% ± 23% | |
| glutamatergic neuron | 5 studies | 43% ± 10% | |
| Mueller cell | 5 studies | 63% ± 29% | |
| glial cell | 4 studies | 56% ± 7% | |
| granule cell | 4 studies | 57% ± 7% | |
| microglial cell | 4 studies | 42% ± 17% | |
| retinal pigment epithelial cell | 4 studies | 41% ± 13% | |
| retina horizontal cell | 4 studies | 50% ± 20% | |
| myofibroblast cell | 4 studies | 31% ± 12% | |
| GABAergic interneuron | 3 studies | 66% ± 12% | |
| endothelial cell | 3 studies | 39% ± 24% | |
| GABAergic amacrine cell | 3 studies | 22% ± 7% | |
| amacrine cell | 3 studies | 43% ± 27% | |
| glycinergic amacrine cell | 3 studies | 41% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1623.52 | 2632 / 2642 | 80% | 4.75 | 562 / 705 |
| adrenal gland | 94% | 318.83 | 243 / 258 | 61% | 2.87 | 140 / 230 |
| prostate | 79% | 338.67 | 194 / 245 | 13% | 0.27 | 64 / 502 |
| intestine | 86% | 435.60 | 829 / 966 | 2% | 0.08 | 10 / 527 |
| thymus | 70% | 201.10 | 460 / 653 | 15% | 0.44 | 89 / 605 |
| esophagus | 67% | 229.42 | 969 / 1445 | 7% | 0.12 | 12 / 183 |
| bladder | 67% | 348.00 | 14 / 21 | 4% | 0.16 | 19 / 504 |
| heart | 49% | 146.11 | 425 / 861 | 0% | 0 | 0 / 0 |
| stomach | 35% | 97.16 | 125 / 359 | 5% | 0.09 | 15 / 286 |
| skin | 6% | 12.92 | 101 / 1809 | 31% | 2.10 | 145 / 472 |
| uterus | 10% | 30.56 | 17 / 170 | 7% | 0.43 | 34 / 459 |
| blood vessel | 14% | 62.52 | 191 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 9% | 24.42 | 103 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 7% | 15.26 | 18 / 241 | 0% | 0 | 0 / 0 |
| ovary | 3% | 8.31 | 6 / 180 | 2% | 0.12 | 10 / 430 |
| lung | 2% | 3.47 | 11 / 578 | 3% | 0.16 | 37 / 1155 |
| breast | 4% | 8.74 | 18 / 459 | 1% | 0.03 | 7 / 1118 |
| kidney | 0% | 0 | 0 / 89 | 4% | 0.18 | 37 / 901 |
| pancreas | 1% | 1.32 | 2 / 328 | 3% | 0.16 | 6 / 178 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.12 | 3 / 80 |
| liver | 0% | 0 | 0 / 226 | 2% | 0.05 | 7 / 406 |
| muscle | 0% | 0.65 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0048387 | Biological process | negative regulation of retinoic acid receptor signaling pathway |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0044323 | Molecular function | retinoic acid-responsive element binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | ZNF536 |
| Protein name | ZNF536 protein Zinc finger protein 536 |
| Synonyms | KIAA0390 |
| Description | FUNCTION: Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription . Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 . Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' . . |
| Accessions | ENST00000706144.1 ENST00000706150.1 ENST00000591488.1 ENST00000706147.1 A7E228 A0A994J5Q4 ENST00000592773.3 A0A994J5C6 ENST00000585628.5 K7EQN6 ENST00000355537.4 ENST00000706149.1 ENST00000706148.1 A0A994J7Z0 ENST00000706143.1 ENST00000706146.1 K7EJP8 O15090 ENST00000706142.1 K7EKT4 |