ZNF536 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045665Biological processnegative regulation of neuron differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0048387Biological processnegative regulation of retinoic acid receptor signaling pathway
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0044323Molecular functionretinoic acid-responsive element binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF536
Protein nameZNF536 protein
Zinc finger protein 536
SynonymsKIAA0390
DescriptionFUNCTION: Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription . Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 . Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' . .

AccessionsENST00000706144.1
ENST00000706150.1
ENST00000591488.1
ENST00000706147.1
A7E228
A0A994J5Q4
ENST00000592773.3
A0A994J5C6
ENST00000585628.5
K7EQN6
ENST00000355537.4
ENST00000706149.1
ENST00000706148.1
A0A994J7Z0
ENST00000706143.1
ENST00000706146.1
K7EJP8
O15090
ENST00000706142.1
K7EKT4