TCF3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TCF3 at tissue level.

III. Associated gene sets

GO_0002326Biological processB cell lineage commitment
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0033152Biological processimmunoglobulin V(D)J recombination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0007399Biological processnervous system development
GO_0030183Biological processB cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0070644Molecular functionvitamin D response element binding
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTCF3
Protein nameTranscription factor 3
Transcription factor E2-alpha (Transcription factor 3)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Alternative protein TCF3
SynonymsBHLHB21
E2A
ITF1
DescriptionFUNCTION: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer . Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). .; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. .

AccessionsK7ENI0
ENST00000592628.5
ENST00000705032.1
ENST00000588136.7 [P15923-2]
K7EPH6
A0A994J7B2
ENST00000587425.5
ENST00000586164.1
K7EK65
L0R8G9
ENST00000651991.1
ENST00000586318.1
ENST00000587235.6
K7ERZ7
A0A494C1R3
A0A0A0MTS0
K7EPS2
ENST00000453954.6
X6REB3
K7EJN4
ENST00000586410.2
K7ENH8
ENST00000593064.5
ENST00000585855.2
U5LXR9
Q6PJU3
ENST00000592395.5
ENST00000590684.5
P15923
ENST00000585731.5
ENST00000262965.12 [P15923-1]
K7EMM4
K7ELF3
K7EKB9
ENST00000590436.5
ENST00000395423.7 [P15923-3]