Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 17 studies | 28% ± 11% | |
| astrocyte | 11 studies | 36% ± 16% | |
| glutamatergic neuron | 9 studies | 38% ± 24% | |
| B cell | 8 studies | 21% ± 5% | |
| macrophage | 8 studies | 25% ± 6% | |
| oligodendrocyte precursor cell | 8 studies | 27% ± 11% | |
| fibroblast | 8 studies | 23% ± 6% | |
| plasmacytoid dendritic cell | 7 studies | 23% ± 7% | |
| GABAergic neuron | 7 studies | 38% ± 18% | |
| interneuron | 6 studies | 36% ± 24% | |
| dendritic cell | 6 studies | 25% ± 5% | |
| neuron | 5 studies | 33% ± 14% | |
| myeloid cell | 5 studies | 25% ± 7% | |
| epithelial cell | 5 studies | 35% ± 16% | |
| endothelial cell of lymphatic vessel | 5 studies | 21% ± 2% | |
| smooth muscle cell | 5 studies | 20% ± 5% | |
| monocyte | 4 studies | 22% ± 2% | |
| type I pneumocyte | 4 studies | 23% ± 5% | |
| GABAergic interneuron | 3 studies | 21% ± 5% | |
| adipocyte | 3 studies | 21% ± 3% | |
| mesothelial cell | 3 studies | 20% ± 4% | |
| ciliated cell | 3 studies | 25% ± 7% | |
| Mueller cell | 3 studies | 19% ± 2% | |
| hepatocyte | 3 studies | 59% ± 22% | |
| T cell | 3 studies | 17% ± 1% | |
| type II pneumocyte | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1710.90 | 1445 / 1445 | 100% | 18.15 | 183 / 183 |
| ovary | 100% | 1825.61 | 180 / 180 | 99% | 9.90 | 427 / 430 |
| stomach | 100% | 1000.14 | 359 / 359 | 99% | 9.79 | 284 / 286 |
| intestine | 100% | 1782.47 | 966 / 966 | 99% | 8.02 | 523 / 527 |
| lung | 100% | 1911.78 | 578 / 578 | 99% | 11.01 | 1144 / 1155 |
| breast | 100% | 2207.12 | 459 / 459 | 99% | 13.58 | 1102 / 1118 |
| prostate | 100% | 1700.40 | 245 / 245 | 97% | 14.09 | 487 / 502 |
| thymus | 100% | 1403.27 | 652 / 653 | 97% | 9.31 | 585 / 605 |
| uterus | 100% | 1592.39 | 170 / 170 | 96% | 8.36 | 441 / 459 |
| pancreas | 99% | 762.34 | 325 / 328 | 97% | 7.56 | 172 / 178 |
| skin | 100% | 2136.72 | 1807 / 1809 | 96% | 8.93 | 452 / 472 |
| bladder | 100% | 1730.14 | 21 / 21 | 94% | 7.45 | 473 / 504 |
| brain | 96% | 979.01 | 2527 / 2642 | 97% | 7.50 | 686 / 705 |
| kidney | 100% | 1085.51 | 89 / 89 | 89% | 6.60 | 800 / 901 |
| adrenal gland | 98% | 831.35 | 254 / 258 | 85% | 6.10 | 195 / 230 |
| liver | 100% | 1553.67 | 226 / 226 | 80% | 4.34 | 325 / 406 |
| adipose | 100% | 2459.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1994.93 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1687.09 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.29 | 1 / 1 |
| muscle | 99% | 911.22 | 796 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 17.43 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 11.90 | 28 / 29 |
| heart | 95% | 901.15 | 815 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 1551.18 | 749 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 3.22 | 60 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005634 | Cellular component | nucleus |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | HIVEP1 |
| Protein name | Alternative protein HIVEP1 Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) HIVEP zinc finger 1 |
| Synonyms | ZNF40 |
| Description | FUNCTION: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| Accessions | C9JZF8 L8EC93 C9JZV1 P15822 ENST00000442081.6 ENST00000487103.5 ENST00000627968.2 ENST00000478545.1 C9JLG1 ENST00000379388.7 [P15822-1] ENST00000399469.2 H7BYU7 ENST00000491710.5 F5H212 A0A0D9SFF3 ENST00000541134.5 C9JAW2 C9J2N3 ENST00000484210.1 |