I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 22% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 22% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3005.95 | 1445 / 1445 | 100% | 35.79 | 183 / 183 |
| brain | 100% | 3264.03 | 2641 / 2642 | 100% | 35.85 | 704 / 705 |
| ovary | 100% | 2467.80 | 180 / 180 | 100% | 32.98 | 429 / 430 |
| lung | 100% | 2807.50 | 577 / 578 | 100% | 29.58 | 1153 / 1155 |
| adrenal gland | 100% | 3348.35 | 258 / 258 | 100% | 35.49 | 229 / 230 |
| breast | 100% | 3012.60 | 459 / 459 | 99% | 58.93 | 1112 / 1118 |
| prostate | 100% | 3387.07 | 245 / 245 | 99% | 33.76 | 499 / 502 |
| bladder | 100% | 3614.57 | 21 / 21 | 99% | 27.84 | 500 / 504 |
| thymus | 100% | 2660.06 | 653 / 653 | 99% | 32.81 | 599 / 605 |
| uterus | 100% | 3658.05 | 170 / 170 | 99% | 28.04 | 454 / 459 |
| liver | 100% | 1773.65 | 226 / 226 | 98% | 23.91 | 398 / 406 |
| pancreas | 99% | 1646.43 | 325 / 328 | 99% | 27.27 | 176 / 178 |
| kidney | 100% | 2241.15 | 89 / 89 | 97% | 25.16 | 878 / 901 |
| stomach | 100% | 2392.30 | 359 / 359 | 97% | 25.91 | 276 / 286 |
| intestine | 100% | 3532.21 | 966 / 966 | 96% | 23.24 | 508 / 527 |
| skin | 99% | 2538.88 | 1795 / 1809 | 91% | 27.05 | 429 / 472 |
| adipose | 100% | 3152.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4263.54 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2947.22 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3454.16 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 19.24 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.00 | 1 / 1 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 35.73 | 28 / 29 |
| heart | 96% | 1647.53 | 824 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 74% | 15.72 | 59 / 80 |
| peripheral blood | 43% | 948.53 | 397 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045814 | Biological process | negative regulation of gene expression, epigenetic |
| GO_0097190 | Biological process | apoptotic signaling pathway |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0048103 | Biological process | somatic stem cell division |
| GO_0051443 | Biological process | positive regulation of ubiquitin-protein transferase activity |
| GO_0048704 | Biological process | embryonic skeletal system morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_2000011 | Biological process | regulation of adaxial/abaxial pattern formation |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0006959 | Biological process | humoral immune response |
| GO_0033092 | Biological process | positive regulation of immature T cell proliferation in thymus |
| GO_0021903 | Biological process | rostrocaudal neural tube patterning |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0007379 | Biological process | segment specification |
| GO_2001234 | Biological process | negative regulation of apoptotic signaling pathway |
| GO_0007420 | Biological process | brain development |
| GO_0031519 | Cellular component | PcG protein complex |
| GO_0000151 | Cellular component | ubiquitin ligase complex |
| GO_0035102 | Cellular component | PRC1 complex |
| GO_0000792 | Cellular component | heterochromatin |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_1990841 | Molecular function | promoter-specific chromatin binding |
| GO_0071535 | Molecular function | RING-like zinc finger domain binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0097027 | Molecular function | ubiquitin-protein transferase activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BMI1 |
| Protein name | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) |
| Synonyms | RNF51 PCGF4 |
| Description | FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A . In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 . . |
| Accessions | ENST00000376663.8 Q5T8Z2 ENST00000416820.5 Q5T8Z6 Q5T8Z4 ENST00000442508.5 ENST00000443519.1 P35226 |
