DUSP22 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	11 studies	20% ± 5%	Explore
plasma cell	8 studies	24% ± 9%	Explore
memory B cell	8 studies	18% ± 1%	Explore
endothelial cell	8 studies	22% ± 4%	Explore
macrophage	8 studies	23% ± 7%	Explore
classical monocyte	7 studies	24% ± 10%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 5%	Explore
epithelial cell	4 studies	21% ± 4%	Explore
ciliated cell	4 studies	22% ± 1%	Explore
oligodendrocyte	4 studies	20% ± 2%	Explore
conventional dendritic cell	3 studies	36% ± 15%	Explore
non-classical monocyte	3 studies	32% ± 8%	Explore
plasmablast	3 studies	29% ± 9%	Explore
platelet	3 studies	20% ± 3%	Explore
fibroblast	3 studies	18% ± 3%	Explore
monocyte	3 studies	19% ± 4%	Explore
glutamatergic neuron	3 studies	24% ± 7%	Explore
dendritic cell	3 studies	33% ± 18%	Explore
microglial cell	3 studies	23% ± 6%	Explore
naive B cell	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	20% ± 3%	Explore
peripheral blood	3 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4801.80	1445 / 1445	100%	14.74	183 / 183
uterus	100%	3827.59	170 / 170	100%	24.39	459 / 459
thymus	100%	3747.97	653 / 653	100%	25.96	604 / 605
lung	100%	4843.57	578 / 578	100%	23.30	1153 / 1155
stomach	100%	3157.04	359 / 359	100%	16.74	285 / 286
breast	100%	4214.73	459 / 459	100%	20.37	1114 / 1118
prostate	100%	3064.51	244 / 245	100%	21.93	502 / 502
skin	100%	3419.19	1801 / 1809	100%	41.20	472 / 472
liver	100%	2013.22	225 / 226	100%	16.95	406 / 406
pancreas	100%	2520.52	328 / 328	99%	21.89	177 / 178
intestine	100%	4990.33	966 / 966	99%	17.57	524 / 527
kidney	100%	2868.10	89 / 89	99%	19.15	895 / 901
brain	99%	2365.73	2622 / 2642	100%	23.01	705 / 705
ovary	100%	2346.89	180 / 180	99%	16.36	425 / 430
bladder	100%	3782.10	21 / 21	99%	17.60	497 / 504
adrenal gland	100%	1959.36	258 / 258	97%	14.45	222 / 230
adipose	100%	4585.65	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	48.77	80 / 80
lymph node	0%	0	0 / 0	100%	47.39	29 / 29
muscle	100%	3504.24	803 / 803	0%	0	0 / 0
spleen	100%	5528.59	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	23.81	45 / 45
ureter	0%	0	0 / 0	100%	17.79	1 / 1
blood vessel	100%	4077.30	1334 / 1335	0%	0	0 / 0
heart	100%	3170.82	858 / 861	0%	0	0 / 0
peripheral blood	97%	5392.13	902 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050860	Biological process	negative regulation of T cell receptor signaling pathway
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0007165	Biological process	signal transduction
GO_0050868	Biological process	negative regulation of T cell activation
GO_0051895	Biological process	negative regulation of focal adhesion assembly
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0016311	Biological process	dephosphorylation
GO_0002710	Biological process	negative regulation of T cell mediated immunity
GO_1903996	Biological process	negative regulation of non-membrane spanning protein tyrosine kinase activity
GO_0030336	Biological process	negative regulation of cell migration
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0042127	Biological process	regulation of cell population proliferation
GO_0031941	Cellular component	filamentous actin
GO_0005886	Cellular component	plasma membrane
GO_0061851	Cellular component	leading edge of lamellipodium
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004726	Molecular function	non-membrane spanning protein tyrosine phosphatase activity
GO_0017018	Molecular function	myosin phosphatase activity
GO_0008138	Molecular function	protein tyrosine/serine/threonine phosphatase activity
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	DUSP22
Protein name	Dual specificity phosphatase 22 Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x)
Synonyms	JSP1 LMWDSP2 MKPX
Description	FUNCTION: Activates the Jnk signaling pathway. .
Accessions	ENST00000603453.5 ENST00000603296.5 ENST00000344450.9 [Q9NRW4-1] S4R3A4 S4R3K1 S4R3M1 ENST00000419235.7 [Q9NRW4-2] Q9NRW4 S4R378 ENST00000605863.5 ENST00000604971.5 S4R459 ENST00000603726.5 ENST00000603881.5 ENST00000603795.5 ENST00000605315.5 ENST00000605035.5

DUSP22 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review