DR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0045995Biological processregulation of embryonic development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006355Biological processregulation of DNA-templated transcription
GO_0051726Biological processregulation of cell cycle
GO_0051302Biological processregulation of cell division
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090043Biological processregulation of tubulin deacetylation
GO_0072686Cellular componentmitotic spindle
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005654Cellular componentnucleoplasm
GO_0017054Cellular componentnegative cofactor 2 complex
GO_0140672Cellular componentATAC complex
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0017025Molecular functionTBP-class protein binding
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDR1
Protein nameDR1
Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta)
Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)
SynonymsDKFZp666G145
hCG_31940
DescriptionFUNCTION: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. .

AccessionsQ658N3
ENST00000370267.1
Q01658
A0A126LB39
ENST00000370272.9