SUPT5H report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0034243Biological processregulation of transcription elongation by RNA polymerase II
GO_0032785Biological processnegative regulation of DNA-templated transcription, elongation
GO_0016239Biological processpositive regulation of macroautophagy
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032044Cellular componentDSIF complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003682Molecular functionchromatin binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSUPT5H
Protein nameTranscription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (Transcription elongation factor spt5)
SPT5 homolog, DSIF elongation factor subunit
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Alternative protein SUPT5H
SynonymsSPT5
SPT5H
hCG_43350
DescriptionFUNCTION: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. .

AccessionsENST00000402194.6 [O00267-2]
ENST00000594990.5
ENST00000601515.5
L8E7T7
M0QYL9
ENST00000359191.10 [O00267-2]
O00267
ENST00000432763.7 [O00267-1]
B4E0Q4
ENST00000593727.1
M0R2M5
M0R105
ENST00000598725.5 [O00267-1]
ENST00000594729.5
ENST00000599117.5 [O00267-1]