SFN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045606Biological processpositive regulation of epidermal cell differentiation
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0006611Biological processprotein export from nucleus
GO_0030307Biological processpositive regulation of cell growth
GO_0061436Biological processestablishment of skin barrier
GO_0007165Biological processsignal transduction
GO_0031424Biological processkeratinization
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0010737Biological processprotein kinase A signaling
GO_0072089Biological processstem cell proliferation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010839Biological processnegative regulation of keratinocyte proliferation
GO_2000647Biological processnegative regulation of stem cell proliferation
GO_0010482Biological processregulation of epidermal cell division
GO_0045824Biological processnegative regulation of innate immune response
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0003334Biological processkeratinocyte development
GO_0043616Biological processkeratinocyte proliferation
GO_0008104Biological processprotein localization
GO_0051726Biological processregulation of cell cycle
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0140311Molecular functionprotein sequestering activity
GO_0050815Molecular functionphosphoserine residue binding
GO_0005515Molecular functionprotein binding
GO_0008426Molecular functionprotein kinase C inhibitor activity

IV. Literature review

[source]
Gene nameSFN
Protein name14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
SynonymsHME1
DescriptionFUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways . Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif . Binding generally results in the modulation of the activity of the binding partner . Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response . Also acts as a TP53/p53-regulated inhibitor of G2/M progression . When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 . .

AccessionsENST00000339276.6 [P31947-1]
P31947