MAFG report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAFG at tissue level.

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_0030534Biological processadult behavior
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001701Biological processin utero embryonic development
GO_0042127Biological processregulation of cell population proliferation
GO_0045604Biological processregulation of epidermal cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameMAFG
Protein nameTranscription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF)
Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G)
Synonyms
DescriptionFUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves . However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites . Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor . Transcription factor, component of erythroid-specific transcription factor NFE2L2 . Activates globin gene expression when associated with NFE2L2 . May be involved in signal transduction of extracellular H(+) (By similarity). .

AccessionsI3L2F8
ENST00000392366.7
ENST00000574686.1
ENST00000357736.9
O15525