USP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045475Biological processlocomotor rhythm
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032922Biological processcircadian regulation of gene expression
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0050821Biological processprotein stabilization
GO_0006508Biological processproteolysis
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0007517Biological processmuscle organ development
GO_0016579Biological processprotein deubiquitination
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0048512Biological processcircadian behavior
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0046872Molecular functionmetal ion binding
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameUSP2
Protein nameUbiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)
Ubiquitin specific peptidase 2
SynonymsUBP41
DescriptionFUNCTION: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 . Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity . Has no deubiquitinase activity against p53/TP53 . Prevents MDM2-mediated degradation of MDM4 . Plays a role in the G1/S cell-cycle progression in normal and cancer cells . Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). .; FUNCTION: [Isoform 4]: Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine. .

AccessionsE9PSH6
ENST00000525735.1 [O75604-4]
ENST00000531070.1
ENST00000260187.7 [O75604-1]
ENST00000527843.1
E9PJ34
O75604
ENST00000455332.6 [O75604-3]