Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 12 studies | 55% ± 19% | |
| type II pneumocyte | 12 studies | 50% ± 18% | |
| epithelial cell | 5 studies | 40% ± 28% | |
| ciliated cell | 5 studies | 25% ± 2% | |
| club cell | 5 studies | 45% ± 19% | |
| basal cell | 4 studies | 23% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| lung | 4 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 21232.70 | 652 / 653 | 86% | 254.77 | 521 / 605 |
| lung | 100% | 6468.64 | 577 / 578 | 46% | 68.35 | 534 / 1155 |
| brain | 27% | 139.30 | 720 / 2642 | 0% | 0.07 | 2 / 705 |
| bladder | 0% | 0 | 0 / 21 | 6% | 8.78 | 28 / 504 |
| stomach | 1% | 1.30 | 2 / 359 | 2% | 1.58 | 7 / 286 |
| uterus | 0% | 0 | 0 / 170 | 2% | 1.53 | 7 / 459 |
| intestine | 0% | 0.67 | 3 / 966 | 1% | 0.36 | 5 / 527 |
| ovary | 1% | 8.23 | 1 / 180 | 0% | 0.54 | 2 / 430 |
| pancreas | 0% | 4.96 | 1 / 328 | 1% | 0.14 | 1 / 178 |
| adrenal gland | 0% | 0 | 0 / 258 | 0% | 0.13 | 1 / 230 |
| spleen | 0% | 0.99 | 1 / 241 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0.71 | 4 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.90 | 4 / 1335 | 0% | 0 | 0 / 0 |
| breast | 0% | 0 | 0 / 459 | 0% | 0.11 | 3 / 1118 |
| skin | 0% | 0.77 | 3 / 1809 | 0% | 0 | 0 / 472 |
| muscle | 0% | 0.28 | 1 / 803 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.20 | 1 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.43 | 1 / 929 | 0% | 0 | 0 / 0 |
| esophagus | 0% | 0.13 | 1 / 1445 | 0% | 0 | 0 / 183 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0 | 0 / 901 |
| liver | 0% | 0 | 0 / 226 | 0% | 0 | 0 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| prostate | 0% | 0 | 0 / 245 | 0% | 0 | 0 / 502 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030324 | Biological process | lung development |
| GO_0021766 | Biological process | hippocampus development |
| GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO_0060510 | Biological process | type II pneumocyte differentiation |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0030900 | Biological process | forebrain development |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0021892 | Biological process | cerebral cortex GABAergic interneuron differentiation |
| GO_0060441 | Biological process | epithelial tube branching involved in lung morphogenesis |
| GO_0021798 | Biological process | forebrain dorsal/ventral pattern formation |
| GO_0060430 | Biological process | lung saccule development |
| GO_0030878 | Biological process | thyroid gland development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0021795 | Biological process | cerebral cortex cell migration |
| GO_0021759 | Biological process | globus pallidus development |
| GO_0009725 | Biological process | response to hormone |
| GO_0060486 | Biological process | club cell differentiation |
| GO_0007492 | Biological process | endoderm development |
| GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0042753 | Biological process | positive regulation of circadian rhythm |
| GO_0048646 | Biological process | anatomical structure formation involved in morphogenesis |
| GO_0030154 | Biological process | cell differentiation |
| GO_1904936 | Biological process | interneuron migration |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0048709 | Biological process | oligodendrocyte differentiation |
| GO_0007420 | Biological process | brain development |
| GO_0006644 | Biological process | phospholipid metabolic process |
| GO_0031128 | Biological process | developmental induction |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0010467 | Biological process | gene expression |
| GO_0021983 | Biological process | pituitary gland development |
| GO_0033327 | Biological process | Leydig cell differentiation |
| GO_0048511 | Biological process | rhythmic process |
| GO_0021854 | Biological process | hypothalamus development |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0021877 | Biological process | forebrain neuron fate commitment |
| GO_0007411 | Biological process | axon guidance |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0001161 | Molecular function | intronic transcription regulatory region sequence-specific DNA binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NKX2-1 |
| Protein name | Homeobox protein Nkx-2.1 Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP) |
| Synonyms | NKX2A TTF1 TITF1 |
| Description | FUNCTION: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). . |
| Accessions | ENST00000522719.4 [P43699-1] P43699 ENST00000354822.7 [P43699-3] ENST00000522719 ENST00000498187.6 [P43699-1] A0A7P0P5T6 ENST00000518149.5 [P43699-1] |
