HAND1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HAND1 at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0003218Biological processcardiac left ventricle formation
GO_0001525Biological processangiogenesis
GO_0007507Biological processheart development
GO_0001947Biological processheart looping
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060411Biological processcardiac septum morphogenesis
GO_0003144Biological processembryonic heart tube formation
GO_0001829Biological processtrophectodermal cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0055010Biological processventricular cardiac muscle tissue morphogenesis
GO_0060536Biological processcartilage morphogenesis
GO_0060707Biological processtrophoblast giant cell differentiation
GO_0060485Biological processmesenchyme development
GO_0001707Biological processmesoderm formation
GO_0035050Biological processembryonic heart tube development
GO_1903026Biological processnegative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO_0003219Biological processcardiac right ventricle formation
GO_0001824Biological processblastocyst development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0001221Molecular functiontranscription coregulator binding
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHAND1
Protein nameHeart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND)
SynonymsBHLHA27
EHAND
DescriptionFUNCTION: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes . .

AccessionsO96004
ENST00000231121.3