Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2056.94 | 1445 / 1445 | 100% | 24.12 | 183 / 183 |
| ovary | 100% | 1427.91 | 180 / 180 | 100% | 23.49 | 430 / 430 |
| lung | 100% | 1809.93 | 578 / 578 | 100% | 23.88 | 1154 / 1155 |
| breast | 100% | 2448.42 | 459 / 459 | 100% | 18.36 | 1116 / 1118 |
| intestine | 100% | 1523.05 | 966 / 966 | 100% | 13.99 | 525 / 527 |
| uterus | 100% | 1676.93 | 170 / 170 | 100% | 28.18 | 457 / 459 |
| thymus | 100% | 1786.34 | 653 / 653 | 100% | 16.80 | 602 / 605 |
| prostate | 100% | 1518.08 | 245 / 245 | 99% | 16.88 | 499 / 502 |
| stomach | 99% | 895.36 | 357 / 359 | 99% | 15.09 | 284 / 286 |
| bladder | 100% | 1779.38 | 21 / 21 | 99% | 14.61 | 497 / 504 |
| kidney | 100% | 884.98 | 89 / 89 | 98% | 17.58 | 887 / 901 |
| brain | 98% | 709.17 | 2584 / 2642 | 100% | 14.74 | 704 / 705 |
| liver | 100% | 979.10 | 226 / 226 | 96% | 9.05 | 390 / 406 |
| adrenal gland | 100% | 1257.64 | 258 / 258 | 95% | 8.37 | 219 / 230 |
| skin | 100% | 2641.18 | 1809 / 1809 | 94% | 13.19 | 446 / 472 |
| pancreas | 96% | 632.66 | 314 / 328 | 98% | 17.93 | 175 / 178 |
| blood vessel | 100% | 1706.51 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 16.68 | 29 / 29 |
| muscle | 100% | 1259.38 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1347.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 42.12 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.61 | 1 / 1 |
| adipose | 100% | 2696.50 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 896.25 | 845 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 82% | 791.86 | 763 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 69% | 5.00 | 55 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0030838 | Biological process | positive regulation of actin filament polymerization |
| GO_0048013 | Biological process | ephrin receptor signaling pathway |
| GO_0036493 | Biological process | positive regulation of translation in response to endoplasmic reticulum stress |
| GO_1903679 | Biological process | positive regulation of cap-independent translational initiation |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_1903676 | Biological process | positive regulation of cap-dependent translational initiation |
| GO_0030032 | Biological process | lamellipodium assembly |
| GO_1902310 | Biological process | positive regulation of peptidyl-serine dephosphorylation |
| GO_0046627 | Biological process | negative regulation of insulin receptor signaling pathway |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_1902237 | Biological process | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| GO_0006930 | Biological process | substrate-dependent cell migration, cell extension |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0007172 | Biological process | signal complex assembly |
| GO_0007015 | Biological process | actin filament organization |
| GO_1903898 | Biological process | negative regulation of PERK-mediated unfolded protein response |
| GO_0033137 | Biological process | negative regulation of peptidyl-serine phosphorylation |
| GO_1903912 | Biological process | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation |
| GO_0042110 | Biological process | T cell activation |
| GO_0016477 | Biological process | cell migration |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0140374 | Biological process | antiviral innate immune response |
| GO_0000164 | Cellular component | protein phosphatase type 1 complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005840 | Cellular component | ribosome |
| GO_0012506 | Cellular component | vesicle membrane |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0004860 | Molecular function | protein kinase inhibitor activity |
| GO_0071074 | Molecular function | eukaryotic initiation factor eIF2 binding |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0046875 | Molecular function | ephrin receptor binding |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0035591 | Molecular function | signaling adaptor activity |
| GO_0140693 | Molecular function | molecular condensate scaffold activity |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0030159 | Molecular function | signaling receptor complex adaptor activity |
| GO_0008093 | Molecular function | cytoskeletal anchor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0030971 | Molecular function | receptor tyrosine kinase binding |
| Gene name | NCK1 |
| Protein name | NCK adaptor protein 1 isoform 2 (NCK adaptor protein 1, isoform CRA_b) NCK adaptor protein 1 NCK adaptor protein 1 isoform 3 NCK adaptor protein 1 isoform 1 SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) |
| Synonyms | NCK hCG_2039389 |
| Description | FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. . |
| Accessions | P16333 ENST00000469404.1 [P16333-2] ENST00000481752.6 [P16333-1] ENST00000491539.5 C9J0K5 ENST00000496489.5 C9JAB9 C9K098 ENST00000488930.5 ENST00000467911.1 A0A0S2Z4D7 A0A0S2Z4E4 ENST00000485096.5 C9J869 A0A0S2Z4Y3 H7C5C7 ENST00000476286.1 C9JVV5 ENST00000288986.6 [P16333-1] |
