RUNX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043371Biological processnegative regulation of CD4-positive, alpha-beta T cell differentiation
GO_0030097Biological processhemopoiesis
GO_0045786Biological processnegative regulation of cell cycle
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0002062Biological processchondrocyte differentiation
GO_0071559Biological processresponse to transforming growth factor beta
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0030182Biological processneuron differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043378Biological processpositive regulation of CD8-positive, alpha-beta T cell differentiation
GO_0045595Biological processregulation of cell differentiation
GO_0048935Biological processperipheral nervous system neuron development
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001503Biological processossification
GO_0006468Biological processprotein phosphorylation
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0016513Cellular componentcore-binding factor complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRUNX3
Protein nameRunt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)
SynonymsAML2
CBFA3
PEBP2A3
DescriptionFUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation . CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). .

AccessionsQ13761
ENST00000308873.11 [Q13761-1]
ENST00000399916.5 [Q13761-2]
ENST00000338888.4 [Q13761-2]