USP3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	22 studies	34% ± 13%	Explore
endothelial cell	20 studies	29% ± 15%	Explore
B cell	18 studies	25% ± 10%	Explore
non-classical monocyte	17 studies	32% ± 14%	Explore
macrophage	16 studies	32% ± 15%	Explore
monocyte	15 studies	32% ± 15%	Explore
CD4-positive, alpha-beta T cell	13 studies	26% ± 6%	Explore
natural killer cell	12 studies	24% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	25% ± 9%	Explore
T cell	11 studies	25% ± 8%	Explore
astrocyte	11 studies	37% ± 15%	Explore
microglial cell	11 studies	33% ± 14%	Explore
CD8-positive, alpha-beta T cell	10 studies	23% ± 4%	Explore
oligodendrocyte precursor cell	10 studies	31% ± 13%	Explore
fibroblast	10 studies	25% ± 9%	Explore
conventional dendritic cell	9 studies	30% ± 18%	Explore
naive B cell	9 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	20% ± 4%	Explore
dendritic cell	9 studies	35% ± 16%	Explore
memory B cell	9 studies	18% ± 2%	Explore
adipocyte	9 studies	29% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	22% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 4%	Explore
mucosal invariant T cell	8 studies	20% ± 4%	Explore
regulatory T cell	8 studies	22% ± 4%	Explore
myeloid cell	8 studies	32% ± 8%	Explore
epithelial cell	8 studies	36% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 6%	Explore
mature NK T cell	7 studies	19% ± 5%	Explore
gamma-delta T cell	7 studies	21% ± 9%	Explore
interneuron	6 studies	35% ± 15%	Explore
plasma cell	6 studies	33% ± 13%	Explore
basal cell	6 studies	28% ± 14%	Explore
ciliated cell	6 studies	29% ± 9%	Explore
type I pneumocyte	6 studies	25% ± 9%	Explore
type II pneumocyte	6 studies	31% ± 10%	Explore
GABAergic neuron	6 studies	35% ± 10%	Explore
pericyte	6 studies	28% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 5%	Explore
leukocyte	5 studies	37% ± 17%	Explore
glutamatergic neuron	5 studies	35% ± 8%	Explore
neuron	5 studies	36% ± 16%	Explore
mast cell	5 studies	23% ± 6%	Explore
mononuclear phagocyte	5 studies	25% ± 9%	Explore
endothelial cell of lymphatic vessel	5 studies	32% ± 12%	Explore
club cell	5 studies	31% ± 10%	Explore
smooth muscle cell	5 studies	24% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	23% ± 6%	Explore
plasmablast	4 studies	31% ± 11%	Explore
lymphocyte	4 studies	40% ± 18%	Explore
abnormal cell	4 studies	31% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 12%	Explore
goblet cell	4 studies	37% ± 32%	Explore
alveolar macrophage	4 studies	42% ± 18%	Explore
oligodendrocyte	4 studies	25% ± 5%	Explore
squamous epithelial cell	3 studies	35% ± 25%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 7%	Explore
hematopoietic precursor cell	3 studies	22% ± 4%	Explore
granule cell	3 studies	49% ± 6%	Explore
progenitor cell	3 studies	33% ± 10%	Explore
precursor B cell	3 studies	24% ± 1%	Explore
immature B cell	3 studies	25% ± 8%	Explore
Mueller cell	3 studies	24% ± 7%	Explore
rod bipolar cell	3 studies	25% ± 12%	Explore
intermediate monocyte	3 studies	50% ± 20%	Explore
hepatocyte	3 studies	41% ± 26%	Explore
neutrophil	3 studies	25% ± 6%	Explore
enteroendocrine cell	3 studies	17% ± 2%	Explore
intestinal crypt stem cell	3 studies	18% ± 3%	Explore
respiratory goblet cell	3 studies	37% ± 15%	Explore
transit amplifying cell	3 studies	29% ± 20%	Explore
brush cell	3 studies	26% ± 13%	Explore
double negative thymocyte	3 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 4%	Explore
mural cell	3 studies	36% ± 18%	Explore
mucus secreting cell	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	27% ± 8%	Explore
brain	11 studies	28% ± 10%	Explore
lung	8 studies	27% ± 9%	Explore
liver	4 studies	25% ± 13%	Explore
adipose	4 studies	26% ± 4%	Explore
bone marrow	3 studies	19% ± 3%	Explore
eye	3 studies	30% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1643.10	1445 / 1445	100%	10.47	183 / 183
intestine	100%	2287.97	966 / 966	100%	10.44	527 / 527
pancreas	100%	1953.84	328 / 328	100%	9.13	178 / 178
prostate	100%	2149.16	245 / 245	100%	10.99	502 / 502
stomach	100%	2081.37	359 / 359	100%	10.47	286 / 286
lung	100%	2254.11	578 / 578	100%	9.45	1153 / 1155
bladder	100%	2022.10	21 / 21	100%	9.80	503 / 504
breast	100%	1788.44	459 / 459	99%	10.80	1112 / 1118
uterus	100%	2077.93	170 / 170	99%	7.67	455 / 459
ovary	100%	2427.84	180 / 180	99%	7.35	426 / 430
kidney	100%	1544.98	89 / 89	99%	8.03	890 / 901
thymus	100%	1642.14	653 / 653	99%	7.28	597 / 605
liver	100%	969.87	226 / 226	97%	5.35	392 / 406
skin	100%	2036.60	1809 / 1809	95%	5.77	448 / 472
brain	95%	1768.17	2503 / 2642	100%	10.11	702 / 705
adrenal gland	100%	1453.58	258 / 258	81%	3.09	187 / 230
adipose	100%	1745.72	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	7.29	29 / 29
spleen	100%	3712.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	6.81	45 / 45
ureter	0%	0	0 / 0	100%	6.90	1 / 1
blood vessel	100%	1589.40	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	3786.95	925 / 929	0%	0	0 / 0
muscle	94%	754.82	751 / 803	0%	0	0 / 0
heart	93%	677.70	805 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	74%	3.06	59 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006281	Biological process	DNA repair
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006508	Biological process	proteolysis
GO_0140861	Biological process	DNA repair-dependent chromatin remodeling
GO_0090543	Cellular component	Flemming body
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005737	Cellular component	cytoplasm
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0005634	Cellular component	nucleus
GO_0140936	Molecular function	histone H2B deubiquitinase activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140950	Molecular function	histone H2A deubiquitinase activity
GO_1990841	Molecular function	promoter-specific chromatin binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0008270	Molecular function	zinc ion binding
GO_0042393	Molecular function	histone binding

IV. Literature review

[source]

Gene name	USP3
Protein name	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) Ubiquitin specific peptidase 3 Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Synonyms
Description	FUNCTION: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .
Accessions	H0YMW1 ENST00000380324.8 [Q9Y6I4-1] H0YLJ0 H0YLG0 ENST00000558285.5 H0YM72 Q9Y6I4 ENST00000559873.5 Q498Y2 ENST00000560202.1 ENST00000557884.5 Q6JHV3 ENST00000268049.11 H0YMI4 H0YKU8 H0YL81 ENST00000559711.5 H0YLB7 H0YNK1 ENST00000561442.5 H0YNX9 ENST00000559192.5 ENST00000540797.5 [Q9Y6I4-2] H0YMP6 ENST00000559276.5 ENST00000560070.5 ENST00000559771.5 ENST00000559257.5 ENST00000558157.5

USP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review