LRRFIP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	47% ± 16%	Explore
natural killer cell	42 studies	43% ± 14%	Explore
B cell	41 studies	41% ± 13%	Explore
macrophage	41 studies	52% ± 19%	Explore
T cell	38 studies	41% ± 13%	Explore
CD8-positive, alpha-beta T cell	38 studies	42% ± 16%	Explore
CD4-positive, alpha-beta T cell	33 studies	46% ± 15%	Explore
pericyte	32 studies	35% ± 16%	Explore
fibroblast	29 studies	29% ± 11%	Explore
dendritic cell	28 studies	59% ± 19%	Explore
smooth muscle cell	28 studies	33% ± 12%	Explore
classical monocyte	28 studies	64% ± 15%	Explore
conventional dendritic cell	27 studies	63% ± 17%	Explore
regulatory T cell	27 studies	41% ± 12%	Explore
mast cell	26 studies	41% ± 16%	Explore
non-classical monocyte	25 studies	73% ± 15%	Explore
monocyte	24 studies	58% ± 20%	Explore
basal cell	24 studies	45% ± 16%	Explore
epithelial cell	24 studies	43% ± 20%	Explore
endothelial cell of lymphatic vessel	22 studies	53% ± 15%	Explore
plasmacytoid dendritic cell	21 studies	54% ± 16%	Explore
mature NK T cell	20 studies	41% ± 10%	Explore
memory B cell	20 studies	42% ± 10%	Explore
naive B cell	20 studies	39% ± 14%	Explore
ciliated cell	19 studies	59% ± 12%	Explore
gamma-delta T cell	18 studies	45% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	36% ± 13%	Explore
myeloid cell	18 studies	56% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	41% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	46% ± 14%	Explore
mucosal invariant T cell	15 studies	36% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	38% ± 15%	Explore
capillary endothelial cell	14 studies	43% ± 11%	Explore
endothelial cell of artery	14 studies	51% ± 13%	Explore
oligodendrocyte precursor cell	14 studies	39% ± 19%	Explore
microglial cell	14 studies	38% ± 16%	Explore
endothelial cell of vascular tree	14 studies	47% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	42% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	47% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	47% ± 13%	Explore
vein endothelial cell	13 studies	48% ± 15%	Explore
type I pneumocyte	12 studies	63% ± 15%	Explore
type II pneumocyte	12 studies	48% ± 16%	Explore
astrocyte	12 studies	27% ± 12%	Explore
club cell	11 studies	43% ± 15%	Explore
neutrophil	11 studies	46% ± 11%	Explore
secretory cell	11 studies	49% ± 15%	Explore
leukocyte	11 studies	47% ± 11%	Explore
GABAergic neuron	10 studies	51% ± 26%	Explore
glutamatergic neuron	10 studies	54% ± 24%	Explore
myofibroblast cell	10 studies	25% ± 14%	Explore
innate lymphoid cell	9 studies	45% ± 10%	Explore
goblet cell	9 studies	32% ± 22%	Explore
abnormal cell	9 studies	30% ± 10%	Explore
hematopoietic stem cell	9 studies	47% ± 17%	Explore
alveolar macrophage	8 studies	76% ± 11%	Explore
respiratory goblet cell	8 studies	46% ± 15%	Explore
platelet	8 studies	31% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	53% ± 15%	Explore
T follicular helper cell	8 studies	44% ± 6%	Explore
connective tissue cell	8 studies	33% ± 15%	Explore
plasma cell	8 studies	25% ± 9%	Explore
mononuclear phagocyte	7 studies	56% ± 11%	Explore
kidney loop of Henle epithelial cell	7 studies	27% ± 9%	Explore
neuron	7 studies	45% ± 18%	Explore
precursor B cell	7 studies	43% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	32% ± 7%	Explore
hematopoietic precursor cell	6 studies	62% ± 17%	Explore
plasmablast	6 studies	44% ± 21%	Explore
ionocyte	6 studies	38% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	54% ± 6%	Explore
enterocyte	6 studies	21% ± 5%	Explore
interneuron	6 studies	56% ± 26%	Explore
lymphocyte	6 studies	54% ± 10%	Explore
mucus secreting cell	6 studies	34% ± 8%	Explore
cardiac muscle cell	6 studies	58% ± 21%	Explore
mesothelial cell	6 studies	38% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	60% ± 12%	Explore
CD4-positive helper T cell	5 studies	42% ± 18%	Explore
exhausted T cell	5 studies	55% ± 13%	Explore
renal principal cell	5 studies	51% ± 10%	Explore
pro-B cell	5 studies	56% ± 15%	Explore
brush cell	5 studies	25% ± 14%	Explore
immature B cell	5 studies	44% ± 15%	Explore
amacrine cell	5 studies	24% ± 10%	Explore
adipocyte	5 studies	22% ± 5%	Explore
double negative thymocyte	5 studies	53% ± 14%	Explore
intermediate monocyte	5 studies	67% ± 21%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	31% ± 10%	Explore
deuterosomal cell	4 studies	33% ± 8%	Explore
duct epithelial cell	4 studies	36% ± 14%	Explore
squamous epithelial cell	4 studies	57% ± 15%	Explore
pancreatic A cell	4 studies	57% ± 17%	Explore
podocyte	4 studies	31% ± 8%	Explore
transit amplifying cell	4 studies	36% ± 28%	Explore
progenitor cell	4 studies	47% ± 16%	Explore
retinal ganglion cell	4 studies	24% ± 6%	Explore
inflammatory macrophage	4 studies	37% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	67% ± 13%	Explore
hepatocyte	4 studies	52% ± 27%	Explore
granulocyte	4 studies	54% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	51% ± 11%	Explore
muscle cell	4 studies	47% ± 13%	Explore
enteroendocrine cell	4 studies	46% ± 10%	Explore
keratinocyte	4 studies	30% ± 8%	Explore
T-helper 17 cell	4 studies	54% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	47% ± 19%	Explore
hillock cell	3 studies	41% ± 6%	Explore
precursor cell	3 studies	35% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	73% ± 13%	Explore
glomerular endothelial cell	3 studies	27% ± 7%	Explore
parietal epithelial cell	3 studies	34% ± 11%	Explore
GABAergic interneuron	3 studies	52% ± 2%	Explore
glial cell	3 studies	22% ± 1%	Explore
granule cell	3 studies	31% ± 11%	Explore
extravillous trophoblast	3 studies	67% ± 4%	Explore
placental villous trophoblast	3 studies	24% ± 7%	Explore
megakaryocyte	3 studies	43% ± 9%	Explore
retinal bipolar neuron	3 studies	19% ± 2%	Explore
serous secreting cell	3 studies	29% ± 12%	Explore
tissue-resident macrophage	3 studies	59% ± 9%	Explore
GABAergic amacrine cell	3 studies	27% ± 5%	Explore
ON-bipolar cell	3 studies	26% ± 6%	Explore
glycinergic amacrine cell	3 studies	27% ± 4%	Explore
erythroblast	3 studies	23% ± 1%	Explore
germinal center B cell	3 studies	35% ± 6%	Explore
cholangiocyte	3 studies	58% ± 11%	Explore
pancreatic ductal cell	3 studies	73% ± 17%	Explore
ependymal cell	3 studies	32% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	52% ± 13%	Explore
T-helper 1 cell	3 studies	60% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	41% ± 11%	Explore
double-positive, alpha-beta thymocyte	3 studies	51% ± 14%	Explore
myoepithelial cell	3 studies	29% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	26% ± 0%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	36% ± 9%	Explore
renal alpha-intercalated cell	3 studies	24% ± 6%	Explore
erythrocyte	3 studies	30% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	43% ± 13%	Explore
peripheral blood	19 studies	50% ± 15%	Explore
brain	16 studies	38% ± 19%	Explore
intestine	10 studies	23% ± 5%	Explore
kidney	8 studies	34% ± 11%	Explore
liver	6 studies	38% ± 12%	Explore
heart	5 studies	43% ± 10%	Explore
uterus	5 studies	38% ± 16%	Explore
adipose	5 studies	29% ± 11%	Explore
lymph node	5 studies	37% ± 13%	Explore
breast	5 studies	38% ± 8%	Explore
pancreas	4 studies	46% ± 20%	Explore
placenta	4 studies	44% ± 12%	Explore
bone marrow	4 studies	45% ± 16%	Explore
prostate	4 studies	47% ± 9%	Explore
esophagus	3 studies	39% ± 9%	Explore
skin	3 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	13169.62	21 / 21	100%	31.30	504 / 504
esophagus	100%	11914.34	1445 / 1445	100%	50.92	183 / 183
prostate	100%	8217.05	245 / 245	100%	44.84	502 / 502
lung	100%	12354.73	578 / 578	100%	35.28	1154 / 1155
breast	100%	8692.71	459 / 459	100%	49.17	1117 / 1118
thymus	100%	6905.11	653 / 653	100%	28.71	604 / 605
intestine	100%	10356.14	966 / 966	100%	34.43	526 / 527
stomach	100%	6857.38	359 / 359	100%	34.91	285 / 286
uterus	100%	11163.21	170 / 170	100%	32.73	457 / 459
kidney	100%	6947.67	89 / 89	99%	34.47	891 / 901
ovary	99%	3644.77	178 / 180	99%	22.85	424 / 430
skin	100%	6865.45	1808 / 1809	95%	32.61	450 / 472
liver	99%	4007.32	224 / 226	95%	16.48	384 / 406
adrenal gland	97%	3835.03	251 / 258	91%	19.75	209 / 230
pancreas	85%	2452.09	279 / 328	99%	46.59	176 / 178
brain	85%	2671.85	2237 / 2642	97%	13.26	683 / 705
adipose	100%	9823.83	1204 / 1204	0%	0	0 / 0
blood vessel	100%	17689.45	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.28	29 / 29
muscle	100%	9372.08	803 / 803	0%	0	0 / 0
spleen	100%	7200.62	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	28.73	1 / 1
heart	98%	7515.99	847 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	33.35	44 / 45
peripheral blood	97%	8956.71	899 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	80%	16.63	64 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0045296	Molecular function	cadherin binding
GO_0003677	Molecular function	DNA binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0005515	Molecular function	protein binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0003725	Molecular function	double-stranded RNA binding

IV. Literature review

[source]

Gene name	LRRFIP1
Protein name	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) LRRFIP1 protein Leucine rich repeat (In FLII) interacting protein 1, isoform CRA_c (Leucine-rich repeat flightless-interacting protein 1) LRR binding FLII interacting protein 1
Synonyms	GCF2 TRIP hCG_2012960 tmp_locus_7
Description	FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. .
Accessions	ENST00000698098.1 ENST00000392000.4 [Q32MZ4-1] ENST00000289175.10 [Q32MZ4-3] C9JTC6 A0A0F7NGI8 Q32MZ4 ENST00000698097.1 Q05D04 Q9BSL6 ENST00000244815.9 [Q32MZ4-2] ENST00000420665.5 A0A8V8TLX7 ENST00000308482.14 [Q32MZ4-4] A0A8V8TMX2

LRRFIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review