ESX1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ESX1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	0%	0.05	2 / 2642	14%	0.41	96 / 705
bladder	0%	0	0 / 21	5%	0.31	25 / 504
esophagus	0%	0	0 / 1445	4%	0.27	7 / 183
uterus	0%	0	0 / 170	4%	0.24	17 / 459
breast	0%	0	0 / 459	3%	0.13	30 / 1118
pancreas	0%	0	0 / 328	2%	0.12	4 / 178
tonsil	0%	0	0 / 0	2%	0.49	1 / 45
stomach	0%	0	0 / 359	2%	0.23	6 / 286
lung	0%	0	0 / 578	2%	0.23	24 / 1155
intestine	0%	0	0 / 966	1%	0.08	7 / 527
ovary	0%	0	0 / 180	1%	0.03	5 / 430
skin	0%	0	0 / 1809	1%	0.03	4 / 472
prostate	0%	0.23	1 / 245	0%	0	0 / 502
liver	0%	0	0 / 226	0%	0.00	1 / 406
thymus	0%	0	0 / 653	0%	0.00	1 / 605
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0	0 / 230
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0	0 / 901
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0051726	Biological process	regulation of cell cycle
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0016607	Cellular component	nuclear speck
GO_0000785	Cellular component	chromatin
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding

Gene name	ESX1
Protein name	Extraembryonic spermatogenesis homeobox 1-like protein Homeobox protein ESX1 (Extraembryonic, spermatogenesis, homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]
Synonyms	ESX1L ESX1R
Description	FUNCTION: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. .
Accessions	A6ZIT8 A6ZIU2 A6ZIU5 ENST00000372588.4 A6ZIS5 A6ZIS2 A6ZIS8 A6ZIU1 A6ZIT4 A6ZIT7 A6ZIU4 A6ZIU7 A6ZIT9 Q8N693 A6ZIT2 A6ZIU0 A6ZIS7 A6ZIV3 A6ZIT1 A6ZIV1 A6ZIV2 A6ZIU9 A6ZIV0 A6ZIT0 A6ZIU8 A6ZIU3 A6ZIS9 A6ZIT5 A6ZIS4 A6ZIT3 A6ZIT6 A6ZIU6 A6ZIS3 A6ZIS6

ESX1 report