METTL13 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of METTL13 at tissue level.

III. Associated gene sets

GO_0032259Biological processmethylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1902807Biological processnegative regulation of cell cycle G1/S phase transition
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity

IV. Literature review

[source]
Gene nameMETTL13
Protein nameeEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)]
SynonymsEEF1AKNMT
CGI-01
KIAA0859
FEAT
DescriptionFUNCTION: Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation . Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' . Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' . Has no activity towards core histones H2A, H2B, H3 and H4 . Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6 . .

AccessionsENST00000367737.9 [Q8N6R0-1]
ENST00000362019.7 [Q8N6R0-3]
ENST00000361735.4 [Q8N6R0-5]
Q8N6R0