SAP30L report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SAP30L at tissue level.

III. Associated gene sets

GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0006355Biological processregulation of DNA-templated transcription
GO_0030336Biological processnegative regulation of cell migration
GO_0005730Cellular componentnucleolus
GO_0070822Cellular componentSin3-type complex
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0000118Cellular componenthistone deacetylase complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0008270Molecular functionzinc ion binding
GO_0031491Molecular functionnucleosome binding
GO_0044378Molecular functionnon-sequence-specific DNA binding, bending
GO_0005515Molecular functionprotein binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding

IV. Literature review

[source]
Gene nameSAP30L
Protein nameHistone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like)
SynonymsNS4ATP2
DescriptionFUNCTION: [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes . Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus . Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA . Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import . .; FUNCTION: [Isoform 2]: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. .; FUNCTION: [Isoform 3]: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1. .

AccessionsENST00000426761.2 [Q9HAJ7-2]
Q9HAJ7
ENST00000297109.11 [Q9HAJ7-1]
ENST00000440364.6 [Q9HAJ7-3]