MAGEF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0097428Biological processprotein maturation by iron-sulfur cluster transfer
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAGEF1
Protein nameMelanoma-associated antigen F1 (MAGE-F1) (MAGE-F1 antigen)
Synonyms
DescriptionFUNCTION: Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair . .

AccessionsQ9HAY2
ENST00000317897.5