E2F7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of E2F7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of E2F7 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0032466Biological processnegative regulation of cytokinesis
GO_0060718Biological processchorionic trophoblast cell differentiation
GO_0032877Biological processpositive regulation of DNA endoreduplication
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001890Biological processplacenta development
GO_0060707Biological processtrophoblast giant cell differentiation
GO_0002040Biological processsprouting angiogenesis
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0070365Biological processhepatocyte differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001217Molecular functionDNA-binding transcription repressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameE2F7
Protein nameE2F transcription factor 7
Transcription factor E2F7 (E2F-7)
Transcription factor E2F7
Synonyms
DescriptionFUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. .

AccessionsENST00000416496.6 [Q96AV8-2]
ENST00000550669.5
H0YHW2
H0YIF4
ENST00000547316.1
ENST00000551058.1
ENST00000322886.12 [Q96AV8-1]
F8VXV5
Q96AV8
F8VSE7
ENST00000552907.5