HES6 | OmnibusX

Name	Number of supported studies	Average coverage
goblet cell	7 studies	33% ± 17%	Explore
ciliated cell	5 studies	25% ± 7%	Explore
deuterosomal cell	4 studies	51% ± 4%	Explore
ionocyte	4 studies	30% ± 12%	Explore
neuroendocrine cell	4 studies	81% ± 10%	Explore
oligodendrocyte precursor cell	4 studies	23% ± 6%	Explore
brush cell	3 studies	65% ± 5%	Explore
epithelial cell	3 studies	19% ± 1%	Explore
glutamatergic neuron	3 studies	21% ± 1%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	1628.66	2640 / 2642	99%	489.45	695 / 705
intestine	100%	1194.66	965 / 966	82%	93.84	432 / 527
stomach	100%	507.01	358 / 359	70%	67.35	200 / 286
uterus	95%	811.51	162 / 170	53%	64.42	241 / 459
lung	87%	328.77	501 / 578	40%	29.22	463 / 1155
pancreas	99%	785.04	324 / 328	24%	13.04	42 / 178
adrenal gland	98%	589.11	254 / 258	22%	21.29	51 / 230
thymus	51%	136.00	331 / 653	53%	27.35	318 / 605
spleen	97%	552.06	233 / 241	0%	0	0 / 0
esophagus	71%	289.67	1021 / 1445	23%	11.89	43 / 183
bladder	52%	229.19	11 / 21	40%	51.01	204 / 504
skin	18%	47.64	334 / 1809	74%	65.64	350 / 472
eye	0%	0	0 / 0	93%	139.29	74 / 80
prostate	63%	199.52	155 / 245	20%	8.68	101 / 502
kidney	75%	240.87	67 / 89	8%	1.97	70 / 901
liver	65%	209.33	147 / 226	14%	4.49	58 / 406
blood vessel	79%	356.06	1059 / 1335	0%	0	0 / 0
muscle	78%	891.21	630 / 803	0%	0	0 / 0
ovary	24%	70.11	43 / 180	48%	22.03	208 / 430
breast	27%	83.88	122 / 459	29%	12.09	323 / 1118
tonsil	0%	0	0 / 0	51%	24.20	23 / 45
peripheral blood	47%	244.41	432 / 929	0%	0	0 / 0
adipose	41%	130.03	498 / 1204	0%	0	0 / 0
heart	38%	108.36	326 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0043433	Biological process	negative regulation of DNA-binding transcription factor activity
GO_0030154	Biological process	cell differentiation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0009952	Biological process	anterior/posterior pattern specification
GO_0050767	Biological process	regulation of neurogenesis
GO_0007399	Biological process	nervous system development
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0046983	Molecular function	protein dimerization activity
GO_0005515	Molecular function	protein binding

Gene name	HES6
Protein name	Hes family bHLH transcription factor 6 Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)
Synonyms	BHLHB41
Description	FUNCTION: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). .
Accessions	ENST00000436051.1 ENST00000409356.1 H7C1R4 ENST00000409002.7 [Q96HZ4-3] ENST00000409182.1 C9JF41 ENST00000450098.1 Q96HZ4 B8ZZP9 H7C020 ENST00000417803.5 ENST00000409160.7 [Q96HZ4-2] ENST00000272937.10 [Q96HZ4-1] B9A070 ENST00000409574.1 [Q96HZ4-4]

HES6 report