JARID2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_1902682Biological processprotein localization to pericentric heterochromatin
GO_0060816Biological processrandom inactivation of X chromosome
GO_0060044Biological processnegative regulation of cardiac muscle cell proliferation
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0001889Biological processliver development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0048536Biological processspleen development
GO_0060038Biological processcardiac muscle cell proliferation
GO_0048538Biological processthymus development
GO_0140718Biological processfacultative heterochromatin formation
GO_0007417Biological processcentral nervous system development
GO_0048863Biological processstem cell differentiation
GO_0010614Biological processnegative regulation of cardiac muscle hypertrophy
GO_0035097Cellular componenthistone methyltransferase complex
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0035098Cellular componentESC/E(Z) complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0046976Molecular functionhistone H3K27 methyltransferase activity
GO_0032452Molecular functionhistone demethylase activity
GO_0061649Molecular functionubiquitin-modified histone reader activity
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameJARID2
Protein nameProtein Jumonji (Jumonji/ARID domain-containing protein 2)
SynonymsJMJ
DescriptionFUNCTION: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis . Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin . Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development . In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). .

AccessionsENST00000341776.7 [Q92833-1]
Q92833
ENST00000397311.4 [Q92833-3]