MNT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MNT at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0090398Biological processcellular senescence
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0051726Biological processregulation of cell cycle
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046983Molecular functionprotein dimerization activity
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0042802Molecular functionidentical protein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameMNT
Protein nameMAX network transcriptional repressor
Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)
SynonymsBHLHD3
ROX
DescriptionFUNCTION: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

AccessionsQ99583
V9GY02
ENST00000575394.1
ENST00000174618.5