DDX5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001837Biological processepithelial to mesenchymal transition
GO_0031053Biological processprimary miRNA processing
GO_0045667Biological processregulation of osteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1902893Biological processregulation of miRNA transcription
GO_0061614Biological processmiRNA transcription
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_2001014Biological processregulation of skeletal muscle cell differentiation
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0045069Biological processregulation of viral genome replication
GO_0043517Biological processpositive regulation of DNA damage response, signal transduction by p53 class mediator
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0030509Biological processBMP signaling pathway
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0045445Biological processmyoblast differentiation
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0009299Biological processmRNA transcription
GO_0030521Biological processandrogen receptor signaling pathway
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0048511Biological processrhythmic process
GO_0030520Biological processestrogen receptor signaling pathway
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0070412Molecular functionR-SMAD binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003724Molecular functionRNA helicase activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0046332Molecular functionSMAD binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0035500Molecular functionMH2 domain binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0036002Molecular functionpre-mRNA binding
GO_0070878Molecular functionprimary miRNA binding
GO_0005516Molecular functioncalmodulin binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDDX5
Protein nameProbable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5)
RNA helicase (EC 3.6.4.13)
DEAD-box helicase 5
Probable ATP-dependent RNA helicase DDX5
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
SynonymsHELR
HLR1
G17P1
DescriptionFUNCTION: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. .

AccessionsENST00000585111.2 [P17844-1]
ENST00000577922.6 [P17844-1]
ENST00000676581.1
J3KTA4
ENST00000581697.5
J3QRQ7
J3QRN5
A0A0G2JLI4
ENST00000578804.5
J3QS97
J3KRZ1
P17844
ENST00000579996.5
ENST00000450599.7 [P17844-1]
B5BUE6
J3QS79
ENST00000581693.5
ENST00000578190.5
A0A7I2V2S0
ENST00000678814.1
ENST00000678757.1
J3QLG9
ENST00000540698.6
J3QR02
ENST00000579091.5
K7EKV0
J3QSF1
ENST00000676785.1 [P17844-1]
J3QKN9
J3KTQ4
ENST00000677726.1
ENST00000583239.6
ENST00000585060.5
ENST00000583212.2
ENST00000581806.5
A0A7I2V5F5
ENST00000585111
ENST00000225792.10 [P17844-1]
ENST00000577787.1
A0A7I2V507
ENST00000676601.1
ENST00000577922
ENST00000578400.5
X6RLV5
J3QR62