CEBPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0050873Biological processbrown fat cell differentiation
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0030324Biological processlung development
GO_0071285Biological processcellular response to lithium ion
GO_1902034Biological processnegative regulation of hematopoietic stem cell proliferation
GO_0045786Biological processnegative regulation of cell cycle
GO_0007219Biological processNotch signaling pathway
GO_0001892Biological processembryonic placenta development
GO_0030225Biological processmacrophage differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0010628Biological processpositive regulation of gene expression
GO_0008203Biological processcholesterol metabolic process
GO_0001889Biological processliver development
GO_0048839Biological processinner ear development
GO_0140467Biological processintegrated stress response signaling
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0043032Biological processpositive regulation of macrophage activation
GO_0002070Biological processepithelial cell maturation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0006351Biological processDNA-templated transcription
GO_0030851Biological processgranulocyte differentiation
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_0007005Biological processmitochondrion organization
GO_0000050Biological processurea cycle
GO_0030099Biological processmyeloid cell differentiation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0055088Biological processlipid homeostasis
GO_0050729Biological processpositive regulation of inflammatory response
GO_0071407Biological processcellular response to organic cyclic compound
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0050872Biological processwhite fat cell differentiation
GO_0051726Biological processregulation of cell cycle
GO_0042593Biological processglucose homeostasis
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1990647Cellular componentC/EBP complex
GO_0036488Cellular componentCHOP-C/EBP complex
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0019900Molecular functionkinase binding
GO_0097677Molecular functionSTAT family protein binding
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCEBPA
Protein nameCCAAT/enhancer-binding protein alpha (C/EBP alpha)
SynonymsCEBP
DescriptionFUNCTION: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes . During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex . In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). .; FUNCTION: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation . .; FUNCTION: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. .

AccessionsENST00000498907.3 [P49715-1]
P49715