PRRX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0048844Biological processartery morphogenesis
GO_0007224Biological processsmoothened signaling pathway
GO_0097150Biological processneuronal stem cell population maintenance
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0072089Biological processstem cell proliferation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0002053Biological processpositive regulation of mesenchymal cell proliferation
GO_0060021Biological processroof of mouth development
GO_0048664Biological processneuron fate determination
GO_0030326Biological processembryonic limb morphogenesis
GO_0010463Biological processmesenchymal cell proliferation
GO_0042472Biological processinner ear morphogenesis
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0070570Biological processregulation of neuron projection regeneration
GO_0042474Biological processmiddle ear morphogenesis
GO_0051216Biological processcartilage development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding
GO_0071837Molecular functionHMG box domain binding

IV. Literature review

[source]
Gene namePRRX1
Protein namePaired related homeobox 1
Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)
SynonymsPMX1
DescriptionFUNCTION: Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process . Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). .; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. .; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. .

AccessionsG3V2N3
P54821
ENST00000367760.7 [P54821-2]
ENST00000497230.2
ENST00000239461.11 [P54821-1]