SUV39H2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SUV39H2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SUV39H2 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0032259Biological processmethylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0007623Biological processcircadian rhythm
GO_0030154Biological processcell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0071456Biological processcellular response to hypoxia
GO_0044725Biological processepigenetic programming in the zygotic pronuclei
GO_0000775Cellular componentchromosome, centromeric region
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0140949Molecular functionhistone H3K9 trimethyltransferase activity
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0046974Molecular functionhistone H3K9 methyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSUV39H2
Protein nameSUV39H2 histone lysine methyltransferase
Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Suppressor of variegation 3-9 homolog 2)
Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
[histone H3]-lysine(9) N-trimethyltransferase (EC 2.1.1.355)
SynonymsKMT1B
DescriptionFUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. .

AccessionsENST00000420416.1
Q5JSS2
ENST00000378331.5
ENST00000354919.11 [Q9H5I1-1]
C9IYH9
ENST00000313519.9 [Q9H5I1-2]
H0Y306
ENST00000358298.6
ENST00000412254.1
G5E9A8
ENST00000378325.7 [Q9H5I1-3]
ENST00000433779.5
C9JMB4
Q9H5I1