CDK6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0010468Biological processregulation of gene expression
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0045786Biological processnegative regulation of cell cycle
GO_0007219Biological processNotch signaling pathway
GO_0007165Biological processsignal transduction
GO_0009615Biological processresponse to virus
GO_2000773Biological processnegative regulation of cellular senescence
GO_0010628Biological processpositive regulation of gene expression
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0021542Biological processdentate gyrus development
GO_0043697Biological processcell dedifferentiation
GO_0051301Biological processcell division
GO_0010389Biological processregulation of G2/M transition of mitotic cell cycle
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0033077Biological processT cell differentiation in thymus
GO_0060218Biological processhematopoietic stem cell differentiation
GO_0048699Biological processgeneration of neurons
GO_0045656Biological processnegative regulation of monocyte differentiation
GO_0045646Biological processregulation of erythrocyte differentiation
GO_1902036Biological processregulation of hematopoietic stem cell differentiation
GO_0042063Biological processgliogenesis
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0021670Biological processlateral ventricle development
GO_0003323Biological processtype B pancreatic cell development
GO_2000145Biological processregulation of cell motility
GO_0045596Biological processnegative regulation of cell differentiation
GO_0014002Biological processastrocyte development
GO_0006468Biological processprotein phosphorylation
GO_0051726Biological processregulation of cell cycle
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0001726Cellular componentruffle
GO_0097131Cellular componentcyclin D1-CDK6 complex
GO_0097132Cellular componentcyclin D2-CDK6 complex
GO_0005813Cellular componentcentrosome
GO_0097133Cellular componentcyclin D3-CDK6 complex
GO_0005654Cellular componentnucleoplasm
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0098770Molecular functionFBXO family protein binding
GO_0005524Molecular functionATP binding
GO_0030332Molecular functioncyclin binding
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameCDK6
Protein nameCyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
SynonymsCDKN6
DescriptionFUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases . .

AccessionsQ00534
ENST00000265734.8
ENST00000424848.3