Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 24% ± 9% | |
type II pneumocyte | 8 studies | 30% ± 11% | |
type I pneumocyte | 7 studies | 22% ± 5% | |
astrocyte | 4 studies | 27% ± 6% | |
oligodendrocyte | 4 studies | 24% ± 4% | |
glomerular endothelial cell | 3 studies | 20% ± 0% | |
epithelial cell | 3 studies | 23% ± 5% | |
mast cell | 3 studies | 19% ± 1% | |
GABAergic neuron | 3 studies | 33% ± 5% | |
glutamatergic neuron | 3 studies | 47% ± 9% | |
club cell | 3 studies | 21% ± 1% | |
capillary endothelial cell | 3 studies | 25% ± 8% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 32% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 3923.47 | 459 / 459 | 100% | 38.30 | 1114 / 1118 |
thymus | 100% | 4504.50 | 652 / 653 | 100% | 36.64 | 603 / 605 |
prostate | 100% | 4095.20 | 245 / 245 | 99% | 20.95 | 499 / 502 |
skin | 100% | 3818.91 | 1808 / 1809 | 99% | 36.86 | 465 / 472 |
brain | 99% | 2372.72 | 2627 / 2642 | 99% | 19.62 | 698 / 705 |
uterus | 100% | 3891.17 | 170 / 170 | 98% | 27.81 | 451 / 459 |
lung | 100% | 7748.30 | 578 / 578 | 98% | 30.15 | 1129 / 1155 |
kidney | 100% | 2216.74 | 89 / 89 | 98% | 29.52 | 880 / 901 |
intestine | 100% | 4152.78 | 965 / 966 | 97% | 18.34 | 511 / 527 |
adrenal gland | 100% | 4433.84 | 258 / 258 | 97% | 15.39 | 222 / 230 |
esophagus | 100% | 5062.45 | 1445 / 1445 | 96% | 24.88 | 175 / 183 |
stomach | 100% | 3113.69 | 358 / 359 | 96% | 21.00 | 274 / 286 |
bladder | 100% | 3725.24 | 21 / 21 | 95% | 21.53 | 481 / 504 |
pancreas | 96% | 1407.37 | 315 / 328 | 98% | 23.34 | 175 / 178 |
ovary | 100% | 5832.19 | 180 / 180 | 92% | 15.42 | 395 / 430 |
adipose | 100% | 3769.69 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6903.48 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 32.30 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 39.76 | 29 / 29 |
spleen | 100% | 3909.81 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 26.37 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.75 | 1 / 1 |
heart | 100% | 3357.75 | 859 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 3713.54 | 894 / 929 | 0% | 0 | 0 / 0 |
muscle | 96% | 1622.74 | 767 / 803 | 0% | 0 | 0 / 0 |
liver | 32% | 307.11 | 72 / 226 | 63% | 7.31 | 257 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0046621 | Biological process | negative regulation of organ growth |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0035330 | Biological process | regulation of hippo signaling |
GO_0016477 | Biological process | cell migration |
GO_0035329 | Biological process | hippo signaling |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0035331 | Biological process | negative regulation of hippo signaling |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0019900 | Molecular function | kinase binding |
GO_0035591 | Molecular function | signaling adaptor activity |
GO_0060090 | Molecular function | molecular adaptor activity |
Gene name | WWC3 |
Protein name | Protein WWC3 WWC3 protein |
Synonyms | KIAA1280 |
Description | FUNCTION: Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. . |
Accessions | ENST00000380861.10 [Q9ULE0-1] I6L9A7 Q9ULE0 |