MACROH2A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0007549Biological processsex-chromosome dosage compensation
GO_0006281Biological processDNA repair
GO_1904815Biological processnegative regulation of protein localization to chromosome, telomeric region
GO_0071169Biological processestablishment of protein localization to chromatin
GO_0061187Biological processregulation of rDNA heterochromatin formation
GO_1902882Biological processregulation of response to oxidative stress
GO_0019216Biological processregulation of lipid metabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1902750Biological processnegative regulation of cell cycle G2/M phase transition
GO_0031507Biological processheterochromatin formation
GO_0006334Biological processnucleosome assembly
GO_1901837Biological processnegative regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0034184Biological processpositive regulation of maintenance of mitotic sister chromatid cohesion
GO_0002082Biological processregulation of oxidative phosphorylation
GO_1903226Biological processpositive regulation of endodermal cell differentiation
GO_0040029Biological processepigenetic regulation of gene expression
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_1902688Biological processregulation of NAD metabolic process
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0005730Cellular componentnucleolus
GO_0000786Cellular componentnucleosome
GO_0000228Cellular componentnuclear chromosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0001740Cellular componentBarr body
GO_0001739Cellular componentsex chromatin
GO_0090734Cellular componentsite of DNA damage
GO_0005721Cellular componentpericentric heterochromatin
GO_0000781Cellular componentchromosome, telomeric region
GO_0000793Cellular componentcondensed chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0160004Molecular functionpoly-ADP-D-ribose modification-dependent protein binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0019901Molecular functionprotein kinase binding
GO_0030527Molecular functionstructural constituent of chromatin
GO_0010385Molecular functiondouble-stranded methylated DNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031490Molecular functionchromatin DNA binding
GO_0000182Molecular functionrDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMACROH2A1
Protein nameMacroH2A.1 histone
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Histone H2A
SynonymsH2AFY
DescriptionFUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template . Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability . DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation . Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes . Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin . .; FUNCTION: [Isoform 1]: Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism . Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (By similarity). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (By similarity). Increases the expression of genes involved in redox metabolism, including SOD3 . .; FUNCTION: [Isoform 2]: In contrast to isoform 1, does not bind poly-ADP-ribose . Represses SOD3 gene expression . .

AccessionsA0A8I5KRC6
B4DJC3
ENST00000304332.8 [O75367-3]
ENST00000687629.1
ENST00000688649.1
ENST00000312469.8 [O75367-2]
D6RCF2
O75367
ENST00000510038.1 [O75367-1]
ENST00000511689.6 [O75367-1]
A0A994J4J7
A0A8I5KS04
ENST00000423969.6
ENST00000506671.5
ENST00000513210.6