SATB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006338Biological processchromatin remodeling
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016363Cellular componentnuclear matrix
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding

IV. Literature review

[source]
Gene nameSATB1
Protein nameDNA-binding protein SATB1
SATB homeobox 1
DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)
Synonyms
DescriptionFUNCTION: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). .

AccessionsC9JGL9
ENST00000457005.5
C9J3I0
ENST00000417717.6 [Q01826-2]
ENST00000452260.6
ENST00000444341.1
C9IZC5
ENST00000457005.6 [Q01826-1]
ENST00000700177.1 [Q01826-1]
ENST00000450898.1
ENST00000700180.1 [Q01826-1]
ENST00000493952.2
ENST00000700178.1 [Q01826-1]
A0A1D5RMP0
ENST00000700179.1 [Q01826-1]
ENST00000415069.5
A0A0B6XK52
H0YN86
C9JP21
ENST00000415069.6 [Q01826-1]
ENST00000338745.11 [Q01826-1]
C9JLL5
ENST00000454909.6 [Q01826-1]
C9J7F3
Q01826
ENST00000440737.5
ENST00000414509.5