BEND3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BEND3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BEND3 at tissue level.

III. Associated gene sets

GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0051260Biological processprotein homooligomerization
GO_1903580Biological processpositive regulation of ATP metabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000183Biological processrDNA heterochromatin formation
GO_0000792Cellular componentheterochromatin
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0000182Molecular functionrDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBEND3
Protein nameBEN domain-containing protein 3
SynonymsKIAA1553
DescriptionFUNCTION: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination . Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities . .

AccessionsENST00000429433.3
ENST00000369042.6
Q5T5X7