DACH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007585Biological processrespiratory gaseous exchange by respiratory system
GO_0060244Biological processnegative regulation of cell proliferation involved in contact inhibition
GO_0030336Biological processnegative regulation of cell migration
GO_0033262Biological processregulation of nuclear cell cycle DNA replication
GO_0044342Biological processtype B pancreatic cell proliferation
GO_2000279Biological processnegative regulation of DNA biosynthetic process
GO_0046545Biological processdevelopment of primary female sexual characteristics
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0001967Biological processsuckling behavior
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDACH1
Protein nameDachshund family transcription factor 1
Dachshund homolog 1 (Dach1)
SynonymsDACH
DescriptionFUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). .

AccessionsENST00000619232.2 [Q9UI36-1]
Q9UI36
ENST00000706275.1
A0A994J5V6
ENST00000706274.1
ENST00000613252.5 [Q9UI36-2]
A0A994J7Q8