Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 37% ± 20% | |
pericyte | 13 studies | 39% ± 21% | |
fibroblast | 8 studies | 33% ± 26% | |
mast cell | 7 studies | 33% ± 27% | |
glutamatergic neuron | 7 studies | 38% ± 26% | |
astrocyte | 6 studies | 44% ± 25% | |
capillary endothelial cell | 6 studies | 37% ± 17% | |
retina horizontal cell | 6 studies | 59% ± 25% | |
Mueller cell | 6 studies | 73% ± 26% | |
podocyte | 5 studies | 76% ± 18% | |
retinal ganglion cell | 5 studies | 49% ± 26% | |
neuron | 4 studies | 62% ± 27% | |
amacrine cell | 4 studies | 57% ± 26% | |
retinal cone cell | 4 studies | 40% ± 32% | |
endothelial cell of artery | 4 studies | 33% ± 16% | |
endothelial cell of vascular tree | 4 studies | 51% ± 28% | |
GABAergic neuron | 4 studies | 28% ± 9% | |
interneuron | 3 studies | 43% ± 5% | |
GABAergic amacrine cell | 3 studies | 33% ± 11% | |
glycinergic amacrine cell | 3 studies | 67% ± 9% | |
myofibroblast cell | 3 studies | 28% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 98% | 1248.44 | 241 / 245 | 94% | 14.63 | 474 / 502 |
breast | 100% | 976.45 | 457 / 459 | 74% | 25.78 | 829 / 1118 |
adrenal gland | 99% | 1285.46 | 255 / 258 | 74% | 15.30 | 170 / 230 |
intestine | 80% | 369.78 | 772 / 966 | 77% | 19.99 | 406 / 527 |
brain | 83% | 643.58 | 2202 / 2642 | 56% | 5.14 | 394 / 705 |
kidney | 100% | 1338.53 | 89 / 89 | 36% | 3.05 | 326 / 901 |
lung | 100% | 979.80 | 577 / 578 | 31% | 3.00 | 359 / 1155 |
uterus | 96% | 495.98 | 164 / 170 | 31% | 6.27 | 140 / 459 |
stomach | 52% | 108.69 | 188 / 359 | 66% | 14.52 | 188 / 286 |
bladder | 81% | 505.95 | 17 / 21 | 29% | 6.14 | 146 / 504 |
ovary | 43% | 94.78 | 77 / 180 | 66% | 12.42 | 282 / 430 |
spleen | 100% | 837.40 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 890.02 | 1200 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 51% | 105.28 | 168 / 328 | 43% | 3.83 | 76 / 178 |
esophagus | 52% | 123.69 | 748 / 1445 | 38% | 5.92 | 69 / 183 |
heart | 87% | 264.19 | 745 / 861 | 0% | 0 | 0 / 0 |
muscle | 75% | 195.34 | 604 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 64% | 303.46 | 597 / 929 | 0% | 0 | 0 / 0 |
skin | 57% | 266.83 | 1031 / 1809 | 4% | 0.55 | 20 / 472 |
liver | 47% | 102.13 | 107 / 226 | 1% | 0.06 | 4 / 406 |
blood vessel | 24% | 70.12 | 319 / 1335 | 0% | 0 | 0 / 0 |
thymus | 7% | 13.07 | 45 / 653 | 10% | 1.07 | 60 / 605 |
tonsil | 0% | 0 | 0 / 0 | 7% | 0.46 | 3 / 45 |
eye | 0% | 0 | 0 / 0 | 4% | 0.32 | 3 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048147 | Biological process | negative regulation of fibroblast proliferation |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0010944 | Biological process | negative regulation of transcription by competitive promoter binding |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0007585 | Biological process | respiratory gaseous exchange by respiratory system |
GO_0060244 | Biological process | negative regulation of cell proliferation involved in contact inhibition |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0033262 | Biological process | regulation of nuclear cell cycle DNA replication |
GO_0044342 | Biological process | type B pancreatic cell proliferation |
GO_2000279 | Biological process | negative regulation of DNA biosynthetic process |
GO_0046545 | Biological process | development of primary female sexual characteristics |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0001967 | Biological process | suckling behavior |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0005515 | Molecular function | protein binding |
Gene name | DACH1 |
Protein name | Dachshund family transcription factor 1 Dachshund homolog 1 (Dach1) |
Synonyms | DACH |
Description | FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). . |
Accessions | ENST00000619232.2 [Q9UI36-1] Q9UI36 ENST00000706275.1 A0A994J5V6 ENST00000706274.1 ENST00000613252.5 [Q9UI36-2] A0A994J7Q8 |