MLXIPL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0070328Biological processtriglyceride homeostasis
GO_0055089Biological processfatty acid homeostasis
GO_0000432Biological processpositive regulation of transcription from RNA polymerase II promoter by glucose
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0045723Biological processpositive regulation of fatty acid biosynthetic process
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_0008610Biological processlipid biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090324Biological processnegative regulation of oxidative phosphorylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0009653Biological processanatomical structure morphogenesis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0045821Biological processpositive regulation of glycolytic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042593Biological processglucose homeostasis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010255Biological processglucose mediated signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0035538Molecular functioncarbohydrate response element binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0046982Molecular functionprotein heterodimerization activity

IV. Literature review

[source]
Gene nameMLXIPL
Protein nameWilliams-Beuren syndrome chromosome region 14 protein 2
MLX interacting-like protein
HCG18989, isoform CRA_h (MLX interacting protein like)
Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)
MLX interacting protein like
SynonymsBHLHD14
MIO
WBSCR14
hCG_18989
DescriptionFUNCTION: Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). .

AccessionsS5M7A5
ENST00000429400.6 [Q9NP71-2]
ENST00000345114.9 [Q9NP71-5]
S5LSP3
ENST00000414749.6 [Q9NP71-3]
Q9NP71
ENST00000453275.1
ENST00000354613.5 [Q9NP71-4]
ENST00000313375.8 [Q9NP71-1]
ENST00000434326.5
C5HU01
C9JDF5
ENST00000456640.2
S5LVX6
H7C1V3
A0A0C4DG26