ZKSCAN3 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	17% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZKSCAN3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	551.43	21 / 21	100%	4.59	503 / 504
prostate	100%	573.37	245 / 245	100%	5.79	501 / 502
breast	100%	501.71	457 / 459	100%	6.52	1114 / 1118
thymus	100%	592.41	653 / 653	99%	4.71	600 / 605
ovary	100%	581.95	180 / 180	99%	5.20	425 / 430
skin	100%	469.71	1805 / 1809	99%	5.99	467 / 472
stomach	100%	463.39	358 / 359	99%	3.76	282 / 286
intestine	100%	562.58	966 / 966	98%	3.59	518 / 527
uterus	100%	676.65	170 / 170	98%	4.53	450 / 459
kidney	100%	386.21	89 / 89	98%	4.63	883 / 901
brain	98%	232.33	2587 / 2642	100%	5.42	705 / 705
pancreas	100%	265.32	327 / 328	98%	3.47	174 / 178
lung	98%	390.76	568 / 578	99%	4.81	1143 / 1155
esophagus	100%	450.25	1443 / 1445	97%	4.12	178 / 183
adrenal gland	99%	502.50	255 / 258	97%	3.67	224 / 230
liver	96%	241.72	216 / 226	96%	5.04	391 / 406
lymph node	0%	0	0 / 0	100%	3.61	29 / 29
spleen	100%	542.15	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.36	1 / 1
adipose	100%	422.18	1202 / 1204	0%	0	0 / 0
blood vessel	100%	363.76	1332 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	5.23	79 / 80
tonsil	0%	0	0 / 0	98%	3.54	44 / 45
heart	97%	252.03	832 / 861	0%	0	0 / 0
muscle	92%	162.28	742 / 803	0%	0	0 / 0
peripheral blood	67%	189.19	620 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007040	Biological process	lysosome organization
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0010507	Biological process	negative regulation of autophagy
GO_0006914	Biological process	autophagy
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_2000773	Biological process	negative regulation of cellular senescence
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

Gene name	ZKSCAN3
Protein name	Zinc finger protein with KRAB and SCAN domains 3 (Zinc finger and SCAN domain-containing protein 13) (Zinc finger protein 306) (Zinc finger protein 309) (Zinc finger protein 47 homolog) (Zf47) (Zfp-47)
Synonyms	ZNF306 ZNF309 ZFP47 ZSCAN13
Description	FUNCTION: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. .
Accessions	Q9BRR0 ENST00000377255.3 [Q9BRR0-1] ENST00000341464.9 [Q9BRR0-2] ENST00000252211.7 [Q9BRR0-1]

ZKSCAN3 report