HSF4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HSF4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HSF4 at tissue level.

III. Associated gene sets

GO_0070306Biological processlens fiber cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0042802Molecular functionidentical protein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameHSF4
Protein nameHeat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)
Heat shock transcription factor 4
Synonyms
DescriptionFUNCTION: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) . Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 . May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization . In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (By similarity). .; FUNCTION: [Isoform HSF4A]: Transcriptional repressor. .; FUNCTION: [Isoform HSF4B]: Transcriptional activator. .

AccessionsENST00000517729.5
Q9ULV5
ENST00000521374.6 [Q9ULV5-1]
ENST00000521624.5
E5RK26
E7EWW4
H0YC14
H0YAU2
H0YAR7
ENST00000522295.5
H0YBG9
ENST00000523562.5
H0YBT7
H0YBS6
ENST00000434833.6
ENST00000519224.5
ENST00000517750.5
ENST00000517685.5
ENST00000521916.1
ENST00000520528.2
ENST00000519601.5
H0YC39
ENST00000521314.5
E5RJV4
ENST00000520304.5
E5RG51
ENST00000584272.5 [Q9ULV5-2]
E5RHY0