CUX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_0050890Biological processcognition
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0051965Biological processpositive regulation of synapse assembly
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_0007614Biological processshort-term memory
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070062Cellular componentextracellular exosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding

IV. Literature review

[source]
Gene nameCUX2
Protein nameNeuron specific transcription factor
Homeobox protein cut-like 2 (Homeobox protein cux-2)
Transcription factor CUX2
Cut like homeobox 2
SynonymsKIAA0293
CUTL2
DescriptionFUNCTION: Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. .

AccessionsENST00000261726.11
Q9BZX3
Q9BZV4
ENST00000397643.3
O14529
F5GWR6