MACROH2A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0007549Biological processsex-chromosome dosage compensation
GO_0071169Biological processestablishment of protein localization to chromatin
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031507Biological processheterochromatin formation
GO_0006334Biological processnucleosome assembly
GO_1901837Biological processnegative regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0007420Biological processbrain development
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0000786Cellular componentnucleosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0001740Cellular componentBarr body
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0030527Molecular functionstructural constituent of chromatin
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMACROH2A2
Protein nameCore histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Histone H2A
MacroH2A.2 histone
SynonymsH2AFY2
DescriptionFUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. .

AccessionsA0A7I2V412
ENST00000676609.1
A0A7I2V4W8
ENST00000677373.1
ENST00000676608.1
ENST00000676896.1
A0A7I2V423
Q9P0M6
A0A7I2V3Z8
Q5SQT3
ENST00000678195.1
A0A7I2V3R0
ENST00000678931.1
ENST00000679349.1
A0A7I2V2N7
ENST00000678523.1
ENST00000676699.1
A0A7I2YQR8
ENST00000678526.1
A0A7I2YQD6
A0A7I2V522
A0A7I2V3M7
ENST00000678762.1
A0A7I2V583
ENST00000678191.1
A0A7I2V3B3
A0A7I2V3C2
ENST00000679292.1
A0A7I2V633
A0A7I2V5G0
ENST00000677894.1
ENST00000373255.9
A0A7I2V5A9
ENST00000678586.1
ENST00000678682.1
ENST00000455786.1
ENST00000677954.1
ENST00000677557.1
A0A7I2V6E9
A0A7I2V4D9
A0A7I2YQF0
ENST00000676692.1
ENST00000678425.1
ENST00000678503.1
ENST00000677881.1
A0A7I2YQB9