Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| dendritic cell | 13 studies | 33% ± 10% | |
| endothelial cell | 7 studies | 24% ± 11% | |
| microglial cell | 7 studies | 28% ± 7% | |
| oligodendrocyte | 6 studies | 22% ± 5% | |
| macrophage | 6 studies | 31% ± 11% | |
| interneuron | 5 studies | 34% ± 18% | |
| oligodendrocyte precursor cell | 5 studies | 25% ± 10% | |
| B cell | 5 studies | 19% ± 2% | |
| epithelial cell | 5 studies | 19% ± 3% | |
| ciliated cell | 5 studies | 19% ± 4% | |
| myeloid cell | 5 studies | 24% ± 8% | |
| GABAergic neuron | 5 studies | 32% ± 17% | |
| astrocyte | 5 studies | 28% ± 8% | |
| glutamatergic neuron | 4 studies | 40% ± 20% | |
| abnormal cell | 3 studies | 26% ± 15% | |
| neuron | 3 studies | 21% ± 4% | |
| memory B cell | 3 studies | 17% ± 0% | |
| naive B cell | 3 studies | 17% ± 1% | |
| effector memory CD8-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
| alveolar macrophage | 3 studies | 25% ± 7% | |
| monocyte | 3 studies | 25% ± 4% | |
| lymphocyte | 3 studies | 27% ± 7% | |
| plasmacytoid dendritic cell | 3 studies | 23% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 7 studies | 31% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1813.05 | 1445 / 1445 | 100% | 11.68 | 183 / 183 |
| stomach | 100% | 1217.34 | 359 / 359 | 100% | 8.67 | 286 / 286 |
| uterus | 100% | 1994.24 | 170 / 170 | 100% | 9.38 | 458 / 459 |
| ovary | 100% | 2055.52 | 180 / 180 | 100% | 10.02 | 429 / 430 |
| breast | 100% | 1583.97 | 459 / 459 | 100% | 8.21 | 1115 / 1118 |
| bladder | 100% | 1773.71 | 21 / 21 | 100% | 7.92 | 502 / 504 |
| lung | 100% | 1986.00 | 578 / 578 | 100% | 7.71 | 1150 / 1155 |
| skin | 100% | 3234.02 | 1809 / 1809 | 99% | 8.97 | 469 / 472 |
| brain | 99% | 1694.45 | 2618 / 2642 | 100% | 10.25 | 705 / 705 |
| intestine | 100% | 1862.40 | 966 / 966 | 99% | 7.49 | 521 / 527 |
| thymus | 100% | 1828.93 | 653 / 653 | 98% | 5.73 | 594 / 605 |
| pancreas | 100% | 931.04 | 327 / 328 | 98% | 5.50 | 174 / 178 |
| kidney | 100% | 1152.11 | 89 / 89 | 96% | 5.17 | 862 / 901 |
| prostate | 100% | 1517.34 | 245 / 245 | 92% | 3.99 | 463 / 502 |
| adrenal gland | 99% | 1139.43 | 256 / 258 | 92% | 3.96 | 211 / 230 |
| liver | 100% | 1077.67 | 226 / 226 | 76% | 3.27 | 309 / 406 |
| adipose | 100% | 1392.25 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 18.09 | 29 / 29 |
| spleen | 100% | 2924.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 10.10 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.98 | 1 / 1 |
| blood vessel | 99% | 1183.44 | 1328 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 837.71 | 793 / 803 | 0% | 0 | 0 / 0 |
| heart | 95% | 740.83 | 819 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 5.16 | 74 / 80 |
| peripheral blood | 92% | 2306.19 | 856 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0021555 | Biological process | midbrain-hindbrain boundary morphogenesis |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0048596 | Biological process | embryonic camera-type eye morphogenesis |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0030900 | Biological process | forebrain development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0021592 | Biological process | fourth ventricle development |
| GO_0006482 | Biological process | protein demethylation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0021678 | Biological process | third ventricle development |
| GO_1902459 | Biological process | positive regulation of stem cell population maintenance |
| GO_0021993 | Biological process | initiation of neural tube closure |
| GO_0021670 | Biological process | lateral ventricle development |
| GO_0030902 | Biological process | hindbrain development |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0030901 | Biological process | midbrain development |
| GO_2000178 | Biological process | negative regulation of neural precursor cell proliferation |
| GO_0031519 | Cellular component | PcG protein complex |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005694 | Cellular component | chromosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0019843 | Molecular function | rRNA binding |
| GO_0003712 | Molecular function | transcription coregulator activity |
| GO_0032452 | Molecular function | histone demethylase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0045322 | Molecular function | unmethylated CpG binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0140680 | Molecular function | histone H3K36me/H3K36me2 demethylase activity |
| GO_0051864 | Molecular function | histone H3K36 demethylase activity |
| Gene name | KDM2B |
| Protein name | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Lysine demethylase 2B |
| Synonyms | FBXL10 NDY1 FBL10 CXXC2 PCCX2 JHDM1B |
| Description | FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code . Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' . Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation . May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). . |
| Accessions | F5H0A1 F5GXW2 Q8NHM5 S4R3G4 ENST00000538046.6 ENST00000377071.9 [Q8NHM5-1] A0A0C4DGG3 ENST00000543852.5 ENST00000611216.4 [Q8NHM5-5] ENST00000541511.1 ENST00000377069.8 [Q8NHM5-4] F5H7T7 F5GXC2 ENST00000541318.1 F5H6N6 ENST00000542030.5 F5H4X4 ENST00000446152.6 ENST00000539394.5 F8WBN2 ENST00000538379.5 ENST00000542973.5 ENST00000543025.5 F5H5W7 ENST00000545022.5 F5H4A7 |