KDM2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021555Biological processmidbrain-hindbrain boundary morphogenesis
GO_0007283Biological processspermatogenesis
GO_0048596Biological processembryonic camera-type eye morphogenesis
GO_0030307Biological processpositive regulation of cell growth
GO_0030900Biological processforebrain development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0021592Biological processfourth ventricle development
GO_0006482Biological processprotein demethylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0021678Biological processthird ventricle development
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0021993Biological processinitiation of neural tube closure
GO_0021670Biological processlateral ventricle development
GO_0030902Biological processhindbrain development
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0030901Biological processmidbrain development
GO_2000178Biological processnegative regulation of neural precursor cell proliferation
GO_0031519Cellular componentPcG protein complex
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0019843Molecular functionrRNA binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0032452Molecular functionhistone demethylase activity
GO_0008270Molecular functionzinc ion binding
GO_0045322Molecular functionunmethylated CpG binding
GO_0005515Molecular functionprotein binding
GO_0140680Molecular functionhistone H3K36me/H3K36me2 demethylase activity
GO_0051864Molecular functionhistone H3K36 demethylase activity

IV. Literature review

[source]
Gene nameKDM2B
Protein nameLysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)
Lysine demethylase 2B
SynonymsFBXL10
NDY1
FBL10
CXXC2
PCCX2
JHDM1B
DescriptionFUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code . Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' . Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation . May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). .

AccessionsF5H0A1
F5GXW2
Q8NHM5
S4R3G4
ENST00000538046.6
ENST00000377071.9 [Q8NHM5-1]
A0A0C4DGG3
ENST00000543852.5
ENST00000611216.4 [Q8NHM5-5]
ENST00000541511.1
ENST00000377069.8 [Q8NHM5-4]
F5H7T7
F5GXC2
ENST00000541318.1
F5H6N6
ENST00000542030.5
F5H4X4
ENST00000446152.6
ENST00000539394.5
F8WBN2
ENST00000538379.5
ENST00000542973.5
ENST00000543025.5
F5H5W7
ENST00000545022.5
F5H4A7