HCLS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	46 studies	44% ± 17%	Explore
natural killer cell	40 studies	42% ± 15%	Explore
B cell	36 studies	41% ± 15%	Explore
CD8-positive, alpha-beta T cell	35 studies	42% ± 17%	Explore
CD4-positive, alpha-beta T cell	31 studies	41% ± 14%	Explore
T cell	28 studies	39% ± 14%	Explore
classical monocyte	27 studies	55% ± 15%	Explore
conventional dendritic cell	27 studies	61% ± 18%	Explore
regulatory T cell	27 studies	52% ± 18%	Explore
non-classical monocyte	24 studies	68% ± 14%	Explore
dendritic cell	23 studies	53% ± 22%	Explore
monocyte	23 studies	44% ± 14%	Explore
memory B cell	20 studies	47% ± 13%	Explore
naive B cell	20 studies	41% ± 12%	Explore
mature NK T cell	19 studies	45% ± 14%	Explore
plasmacytoid dendritic cell	19 studies	39% ± 14%	Explore
gamma-delta T cell	18 studies	47% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	37% ± 15%	Explore
myeloid cell	17 studies	43% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	53% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	45% ± 14%	Explore
mucosal invariant T cell	15 studies	45% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	50% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	42% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	50% ± 17%	Explore
microglial cell	13 studies	38% ± 17%	Explore
plasma cell	12 studies	36% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	51% ± 14%	Explore
neutrophil	11 studies	36% ± 14%	Explore
plasmablast	9 studies	50% ± 19%	Explore
leukocyte	9 studies	31% ± 7%	Explore
alveolar macrophage	8 studies	28% ± 6%	Explore
innate lymphoid cell	8 studies	32% ± 14%	Explore
mast cell	7 studies	21% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	53% ± 23%	Explore
T follicular helper cell	7 studies	45% ± 13%	Explore
CD4-positive helper T cell	6 studies	29% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	43% ± 18%	Explore
hematopoietic precursor cell	6 studies	34% ± 12%	Explore
mononuclear phagocyte	6 studies	50% ± 16%	Explore
precursor B cell	6 studies	45% ± 15%	Explore
immature B cell	6 studies	52% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	51% ± 19%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	46% ± 19%	Explore
exhausted T cell	5 studies	62% ± 7%	Explore
hematopoietic stem cell	5 studies	29% ± 8%	Explore
lymphocyte	5 studies	34% ± 13%	Explore
pro-B cell	5 studies	33% ± 11%	Explore
T-helper 17 cell	5 studies	44% ± 15%	Explore
intermediate monocyte	5 studies	66% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	77% ± 8%	Explore
double negative thymocyte	4 studies	55% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	55% ± 19%	Explore
platelet	3 studies	26% ± 12%	Explore
monocyte-derived dendritic cell	3 studies	48% ± 23%	Explore
tissue-resident macrophage	3 studies	48% ± 9%	Explore
intraepithelial lymphocyte	3 studies	41% ± 13%	Explore
germinal center B cell	3 studies	59% ± 17%	Explore
inflammatory macrophage	3 studies	44% ± 6%	Explore
granulocyte	3 studies	25% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 6%	Explore
T-helper 1 cell	3 studies	59% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	52% ± 19%	Explore
erythrocyte	3 studies	31% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	47% ± 14%	Explore
lung	7 studies	24% ± 9%	Explore
lymph node	4 studies	46% ± 4%	Explore
liver	4 studies	25% ± 10%	Explore
intestine	3 studies	19% ± 3%	Explore
bone marrow	3 studies	42% ± 18%	Explore
brain	3 studies	34% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	8989.89	578 / 578	93%	47.98	1076 / 1155
breast	97%	3504.86	444 / 459	93%	30.31	1045 / 1118
thymus	94%	2497.19	614 / 653	88%	38.82	531 / 605
bladder	100%	2995.86	21 / 21	78%	34.57	393 / 504
uterus	85%	1700.57	144 / 170	87%	35.25	398 / 459
kidney	81%	2592.96	72 / 89	89%	40.12	798 / 901
prostate	90%	2420.89	220 / 245	71%	12.15	354 / 502
intestine	93%	4139.07	894 / 966	67%	16.70	351 / 527
adrenal gland	97%	3312.91	250 / 258	56%	11.10	129 / 230
stomach	78%	1811.55	281 / 359	71%	17.42	204 / 286
liver	72%	1461.65	163 / 226	65%	14.15	263 / 406
skin	54%	1007.77	973 / 1809	79%	35.05	374 / 472
esophagus	67%	1534.38	969 / 1445	63%	12.99	115 / 183
pancreas	33%	597.50	108 / 328	94%	40.94	167 / 178
brain	26%	575.02	676 / 2642	94%	44.37	662 / 705
ovary	48%	928.63	87 / 180	63%	12.26	270 / 430
adipose	100%	6081.76	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	387.11	29 / 29
peripheral blood	100%	50597.07	929 / 929	0%	0	0 / 0
spleen	100%	36975.63	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	59.59	1 / 1
tonsil	0%	0	0 / 0	93%	44.99	42 / 45
blood vessel	86%	2936.05	1144 / 1335	0%	0	0 / 0
heart	65%	1354.49	560 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	28%	6.04	22 / 80
muscle	16%	230.96	128 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0045651	Biological process	positive regulation of macrophage differentiation
GO_0030833	Biological process	regulation of actin filament polymerization
GO_0007165	Biological process	signal transduction
GO_0030854	Biological process	positive regulation of granulocyte differentiation
GO_2000107	Biological process	negative regulation of leukocyte apoptotic process
GO_0042307	Biological process	positive regulation of protein import into nucleus
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0051169	Biological process	nuclear transport
GO_0030218	Biological process	erythrocyte differentiation
GO_0009725	Biological process	response to hormone
GO_0071345	Biological process	cellular response to cytokine stimulus
GO_0035556	Biological process	intracellular signal transduction
GO_0038158	Biological process	granulocyte colony-stimulating factor signaling pathway
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0007015	Biological process	actin filament organization
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005886	Cellular component	plasma membrane
GO_0030139	Cellular component	endocytic vesicle
GO_0005739	Cellular component	mitochondrion
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0019901	Molecular function	protein kinase binding
GO_0051015	Molecular function	actin filament binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0005515	Molecular function	protein binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	HCLS1
Protein name	Hematopoietic cell-specific Lyn substrate 1 Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)
Synonyms	HS1
Description	FUNCTION: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Accessions	ENST00000495491.5 [P14317-2] E7EVW7 ENST00000497391.5 ENST00000464274.5 F8WEZ6 ENST00000428394.6 ENST00000314583.8 [P14317-1] P14317 F8WDD5

HCLS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review