ARX report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ARX at tissue level.

III. Associated gene sets

GO_0035265Biological processorgan growth
GO_0021846Biological processcell proliferation in forebrain
GO_0021853Biological processcerebral cortex GABAergic interneuron migration
GO_0044241Biological processlipid digestion
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0021759Biological processglobus pallidus development
GO_0072148Biological processepithelial cell fate commitment
GO_0050678Biological processregulation of epithelial cell proliferation
GO_0021800Biological processcerebral cortex tangential migration
GO_0021831Biological processembryonic olfactory bulb interneuron precursor migration
GO_0046622Biological processpositive regulation of organ growth
GO_0007411Biological processaxon guidance
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARX
Protein nameHomeobox protein ARX (Aristaless-related homeobox)
Aristaless related homeobox
Synonyms
DescriptionFUNCTION: Transcription factor . Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C . Positively modulates transcription of KDM5C . Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements . Required for normal brain development . Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). .

AccessionsQ96QS3
A0A1B0GUI3
ENST00000379044.5
ENST00000637993.1