FOXL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FOXL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXL2 at tissue level.

III. Associated gene sets

GO_0060014Biological processgranulosa cell differentiation
GO_0001541Biological processovarian follicle development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0002074Biological processextraocular skeletal muscle development
GO_0019101Biological processfemale somatic sex determination
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0001555Biological processoocyte growth
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0060065Biological processuterus development
GO_0009653Biological processanatomical structure morphogenesis
GO_0033686Biological processpositive regulation of luteinizing hormone secretion
GO_0046881Biological processpositive regulation of follicle-stimulating hormone secretion
GO_0006309Biological processapoptotic DNA fragmentation
GO_0007338Biological processsingle fertilization
GO_0048048Biological processembryonic eye morphogenesis
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0090543Cellular componentFlemming body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0043028Molecular functioncysteine-type endopeptidase regulator activity involved in apoptotic process
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXL2
Protein nameForkhead box protein L2
Forkhead box L2
Synonyms
DescriptionFUNCTION: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. .

AccessionsA0A8B0T273
A0A8B0SXM7
Q4JHB5
Q53ZD3
A0A8B0SX55
ENST00000648323.1
A0A8B0SWN0
A0A8B0SXZ5
A0A8B0SXP0
A0A8B0SX42
A0A8B0SY07
Q4JHB6
A0A8B0T278
Q05CX9
A0A8B0SUP7
A0AA96HC68
P58012
A0A8B0T146
A0A8B0SY93
A0A8B0SWK9
A0A8B0T069
Q4JHB7
A0A8B0SUS0