PATZ1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PATZ1 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0002682Biological processregulation of immune system process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030217Biological processT cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001817Biological processregulation of cytokine production
GO_0006355Biological processregulation of DNA-templated transcription
GO_0008584Biological processmale gonad development
GO_0010596Biological processnegative regulation of endothelial cell migration
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePATZ1
Protein namePOZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein)
SynonymsZBTB19
RIAZ
PATZ
ZNF278
ZSG
DescriptionFUNCTION: Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis . Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 . Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions . .; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. .

AccessionsQ9HBE1
ENST00000405309.7 [Q9HBE1-2]
ENST00000266269.10 [Q9HBE1-1]
ENST00000351933.8 [Q9HBE1-3]
ENST00000215919.3 [Q9HBE1-4]