ZBTB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	22% ± 8%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 6%	Explore
gamma-delta T cell	13 studies	26% ± 12%	Explore
B cell	12 studies	19% ± 4%	Explore
macrophage	12 studies	26% ± 10%	Explore
endothelial cell	11 studies	27% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	29% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	23% ± 6%	Explore
T cell	8 studies	22% ± 6%	Explore
naive B cell	8 studies	21% ± 4%	Explore
mature NK T cell	8 studies	22% ± 4%	Explore
regulatory T cell	8 studies	21% ± 5%	Explore
oligodendrocyte	8 studies	27% ± 9%	Explore
CD4-positive, alpha-beta T cell	7 studies	19% ± 4%	Explore
microglial cell	7 studies	26% ± 10%	Explore
memory B cell	7 studies	21% ± 4%	Explore
mucosal invariant T cell	7 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	30% ± 6%	Explore
astrocyte	7 studies	31% ± 14%	Explore
plasmacytoid dendritic cell	6 studies	20% ± 5%	Explore
epithelial cell	6 studies	29% ± 8%	Explore
adipocyte	6 studies	26% ± 8%	Explore
fibroblast	6 studies	22% ± 5%	Explore
leukocyte	5 studies	22% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	29% ± 8%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 7%	Explore
GABAergic neuron	5 studies	36% ± 17%	Explore
classical monocyte	4 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
non-classical monocyte	4 studies	25% ± 3%	Explore
myeloid cell	4 studies	24% ± 5%	Explore
lymphocyte	4 studies	26% ± 8%	Explore
basal cell	4 studies	23% ± 9%	Explore
innate lymphoid cell	4 studies	24% ± 6%	Explore
oligodendrocyte precursor cell	4 studies	29% ± 9%	Explore
monocyte	4 studies	19% ± 1%	Explore
pericyte	4 studies	19% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	27% ± 4%	Explore
conventional dendritic cell	3 studies	26% ± 5%	Explore
ciliated cell	3 studies	27% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
glutamatergic neuron	3 studies	51% ± 15%	Explore
dendritic cell	3 studies	28% ± 10%	Explore
connective tissue cell	3 studies	20% ± 3%	Explore
mast cell	3 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	16% ± 1%	Explore
double negative thymocyte	3 studies	28% ± 13%	Explore
interneuron	3 studies	39% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	23% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	24% ± 3%	Explore
brain	6 studies	36% ± 14%	Explore
bone marrow	3 studies	17% ± 1%	Explore
lung	3 studies	17% ± 1%	Explore
adipose	3 studies	20% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2259.22	1445 / 1445	100%	22.45	183 / 183
lung	100%	2675.51	577 / 578	100%	21.09	1154 / 1155
prostate	100%	3370.53	245 / 245	100%	25.12	500 / 502
breast	100%	2709.50	459 / 459	99%	25.61	1112 / 1118
intestine	100%	2821.17	966 / 966	99%	18.29	524 / 527
bladder	100%	2872.33	21 / 21	99%	18.62	501 / 504
brain	99%	1386.55	2627 / 2642	100%	20.97	704 / 705
ovary	100%	2683.20	180 / 180	99%	15.61	425 / 430
stomach	100%	1925.33	359 / 359	99%	17.40	282 / 286
thymus	100%	3189.83	653 / 653	98%	23.20	595 / 605
pancreas	100%	1319.58	327 / 328	98%	21.66	175 / 178
uterus	100%	2956.22	170 / 170	98%	20.37	449 / 459
kidney	100%	2073.49	89 / 89	98%	18.44	880 / 901
adrenal gland	100%	1957.93	258 / 258	94%	12.73	217 / 230
skin	100%	3025.61	1809 / 1809	93%	18.15	440 / 472
liver	100%	1189.23	226 / 226	78%	7.55	316 / 406
blood vessel	100%	2927.44	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.55	29 / 29
spleen	100%	3933.78	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	9.25	1 / 1
adipose	100%	2886.37	1203 / 1204	0%	0	0 / 0
muscle	100%	1769.87	800 / 803	0%	0	0 / 0
heart	97%	1467.60	836 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	19.75	43 / 45
peripheral blood	70%	2162.63	652 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	57%	7.19	46 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051260	Biological process	protein homooligomerization
GO_0006281	Biological process	DNA repair
GO_0045582	Biological process	positive regulation of T cell differentiation
GO_0034644	Biological process	cellular response to UV
GO_0045087	Biological process	innate immune response
GO_0002711	Biological process	positive regulation of T cell mediated immunity
GO_0006974	Biological process	DNA damage response
GO_0002682	Biological process	regulation of immune system process
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_2000176	Biological process	positive regulation of pro-T cell differentiation
GO_0033077	Biological process	T cell differentiation in thymus
GO_0032825	Biological process	positive regulation of natural killer cell differentiation
GO_0048538	Biological process	thymus development
GO_0001817	Biological process	regulation of cytokine production
GO_0042789	Biological process	mRNA transcription by RNA polymerase II
GO_0019985	Biological process	translesion synthesis
GO_0030183	Biological process	B cell differentiation
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0070530	Molecular function	K63-linked polyubiquitin modification-dependent protein binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0046872	Molecular function	metal ion binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ZBTB1
Protein name	Zinc finger and BTB domain containing 1 Zinc finger and BTB domain-containing protein 1
Synonyms	KIAA0997
Description	FUNCTION: Acts as a transcriptional repressor . Represses cAMP-responsive element (CRE)-mediated transcriptional activation . In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis . Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). .
Accessions	ENST00000553583.1 G3V2I8 Q9Y2K1 ENST00000358738.3 [Q9Y2K1-2] ENST00000555321.1 G3V447 ENST00000554015.5 [Q9Y2K1-1] ENST00000556965.1 ENST00000683701.1 [Q9Y2K1-1] G3V3N0

ZBTB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review