PAX5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAX5 at tissue level.

III. Associated gene sets

GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0006366Biological processtranscription by RNA polymerase II
GO_0021987Biological processcerebral cortex development
GO_0048856Biological processanatomical structure development
GO_0007283Biological processspermatogenesis
GO_0035914Biological processskeletal muscle cell differentiation
GO_0021670Biological processlateral ventricle development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030183Biological processB cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0030534Biological processadult behavior
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene namePAX5
Protein nameB cell specific activator protein variant insert 6/7 (Paired box 5)
B cell specific activator protein variant delta 8
B cell specific activator protein variant delta 8/9
B cell specific activator protein variant delta 6/7/8
B cell specific activator protein variant A delta 2/8/9
B cell specific activator protein variant B delta 3/4
B cell specific activator protein variant B delta 2/3
B cell specific activator protein variant delta 6/7/8/9
B cell specific activator protein BSAP (B-cell specific transcription factor) (PAX5) (Transcription factor Pax-5)
B cell specific activator protein variant delta 7/8
B-cell specific transcription factor (PAX5) (Tanscription factor PAX 5)
Paired box 5
B cell specific activator protein variant delta 7
Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)
B cell specific activator protein variant delta 7/8/9
B cell specific activator protein
B cell specific activator protein variant B delta 2
B cell specific activator protein variant A delta 2
SynonymsPAX-5
DescriptionFUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage . Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes . In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage . Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire . .; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription . Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity . .

AccessionsC0KTE2
ENST00000446742.5 [Q02548-10]
C0KTF0
ENST00000523241.6
C0KTE9
ENST00000523493.5 [Q02548-11]
ENST00000377852.7 [Q02548-6]
ENST00000651550.1
C0KTE1
ENST00000524340.5
E7ES87
C0KTE3
Q9BXX4
ENST00000522932.1
C0KTE4
E7ERK2
ENST00000520154.6
ENST00000377847.6 [Q02548-7]
C0KTF3
C0KTE8
ENST00000377840.6 [Q02548-5]
Q02548
ENST00000414447.5 [Q02548-8]
ENST00000377853.6 [Q02548-2]
E7EQT0
C0KTE5
C0KTE6
C0KTF5
E7ERW5
C0KTF2
C0KTF4
ENST00000523145.5
H0YB47
ENST00000520281.5 [Q02548-9]
C0KTE7
Q93057
ENST00000522003.5
ENST00000358127.9 [Q02548-1]